Gut Hormones/Other Circulatory Regulators of Appetite

肠道激素/其他食欲循环调节剂

• 批准号: 7057489
• 负责人: STEPHEN R BLOOM
• 金额: $ 1.9万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7057489
• 关键词: appetite; appetite regulatory center; bioenergetics; gastrointestinal hormones; meeting /conference /symposium; obesity; travel

DESCRIPTION (provided by applicant): Circulating factors are important in regulating energy balance. It has long been recognized that the adipose hormone, leptin, reduces food intake by specific CNS pathways. Gut hormones have also been shown to be major regulators of appetite, acting both in the brainstem and hypothalamus. In addition, they have been found to markedly influence energy expenditure. Obesity is associated with a reduced gut hormone release but the mechanism is unknown. In man, this change may perpetuate or contribute to obesity. This meeting will address the physiological importance of circulating hormones in the regulation of energy balance. We will explore the mechanisms involved, their disturbance in obesity and therapeutic possibilities. Obesity produces over 6,000 excess deaths a week in the USA alone, yet there is no really effective treatment. This meeting is to advance the most promising approach to a safe practical therapy seen in the last 50 years.

描述(由申请人提供)： 循环因素是调节能量平衡的重要因素。长期以来，人们一直认为脂肪激素瘦素通过特定的中枢神经系统途径减少食物摄入量。胃肠激素也被证明是食欲的主要调节器，作用于脑干和下丘脑。此外，它们还被发现显著影响能量消耗。肥胖与肠道激素释放减少有关，但其机制尚不清楚。在人类身上，这种变化可能会永久存在或导致肥胖。本次会议将讨论循环荷尔蒙在调节能量平衡中的生理重要性。我们将探索其中涉及的机制、它们对肥胖的干扰以及治疗的可能性。单单在美国，肥胖每周就会导致6000多人死亡，但目前还没有真正有效的治疗方法。这次会议是为了推进过去50年来最有希望的安全实用疗法的方法。