Structural Genomics

描述（由申请人提供）：2006年Keystone结构基因组学会议将提供一个讨论快速、平行和经济有效的结构生物学方法领域的进展和技术进步的场所。主讲人和特邀演讲者都是生物信息学、蛋白质表达/纯化、样品制备、x射线晶体学、溶液核磁共振光谱、蛋白质生物物理表征、功能注释和基于结构的药物发现等领域的思想领袖。主题演讲和定期会议涵盖以下主题：-选择既增加我们对蛋白质结构的了解又加强生物医学研究的目标。-用于溶液核磁共振光谱和x射线晶体学样品制备的高效平行方法。-自动化数据缩减、结构确定、细化和数据沉积。-新的蛋白质结构的功能注释的计算和实验方法。-深入了解蛋白质基因家族的结构、功能和进化。-高通量结构研究在重要生物医学问题和药物发现中的应用。海报会议为与会者，特别是年轻科学家，以及世界各地结构基因组学中心和联盟的详细报告提供了机会。蛋白质是构成细胞并完成细胞工作的分子机器。它们也是大多数治疗药物的靶点。本次会议将重点讨论快速有效地确定所有蛋白质的三维形状的方法和策略，以便我们更好地了解它们是如何工作的，以及如何利用它们用于治疗目的。

DESCRIPTION (provided by applicant): The 2006 Keystone Structural Genomics Meeting will provide a venue for discussion of progress and technical advances in the field of rapid, parallel, and economically efficient methods for structural biology. Keynote and Invited Speakers are all thought leaders in the areas of Bioinformatics, Protein Expression/ Purification, Sample Preparation, X-ray Crystallography, Solution NMR Spectroscopy, Biophysical characterization of proteins, Functional Annotation, and Structure-Based Drug Discovery. Keynote and Regular Sessions cover the following topics: - Selection of targets that both increase our knowledge of protein structure and enhance biomedical research. - Efficient parallel methods for sample preparation for solution NMR spectroscopy and X-ray crystallography. - Automated data reduction, structure determination, refinement, and data deposition. - Computational and experimental approaches to functional annotation of new protein structures. - Insights into structure, function and evolution of protein gene families. - Applications of high-throughput structural studies to important biomedical problems and drug discovery. Poster Sessions provide opportunity for presentations by conferees, particularly Younger Scientists, as well as detailed presentations by Structural Genomics Centers and Consortia throughout the world. Proteins are the molecular machines that make up and carry out the work of a cell. They are also the targets for most therapeutic drugs. This meeting will focus on methods and strategies to rapidly and efficiently determine the 3-dimensional shapes of all proteins so that we better understand how they work and how to harness them for therapeutic purposes.