Hypoxia and Development, Physiology and Disease

描述(申请人提供)：缺氧，或“缺氧”，细胞在胚胎发育过程中遇到，并在各种疾病，如中风，心脏病发作，癌症。开发影响细胞氧信号通路的药物应该能为这些常见疾病的患者带来更好的治疗。目前对缺氧的研究主要集中在(1)细胞如何感知氧气供应的变化，(2)缺氧诱导因子如何调节正常发育和生理，以及(3)氧气供应如何影响实体瘤、肺动脉高压和组织缺血等疾病。该领域的主要问题包括了解缺氧时细胞内发生的多种变化。这次会议的目标是将研究酵母、苍蝇、蠕虫、哺乳动物、发育、组织动态平衡、疾病和药物发现的低氧研究人员聚集在一起。

DESCRIPTION (provided by applicant): Oxygen deprivation, or "hypoxia", is encountered by cells during embryonic development, and in a variety of diseases such as stroke, heart attacks, and cancer. Developing drugs that impact cellular oxygen signaling pathways should yield better treatments for patients with these common illnesses. Research on hypoxia is currently focusing on (1) how cells sense changes in oxygen availability, (2) how hypoxia-inducible factors regulate normal development and physiology, and (3) how oxygen availability effects diseases such as solid tumors, pulmonary hypertension, and tissue ischemia. Major problems in the field include understanding multiple intracellular changes that occur upon oxygen deprivation. The goal of this meeting is to bring together hypoxia researchers studying yeast, fly, worm, mammals, development, tissue homeostasis, disease, and drug discovery.