PDE-5 Inhibition in HIV+ and HIV- Men

描述(由申请者提供)：拟议的会议将讨论在感染艾滋病毒或有感染艾滋病毒风险的男性中使用PDE-5带来的潜在公共健康风险。将涉及的具体问题包括：1)使用PDE-5与高危性行为之间的联系，2)使用PDE-5与使用非法药物之间的关系，以及3)为正在接受包括艾滋病毒在内的其他医疗问题治疗的男性开PDE-5的处方。会议计划于2005年5月6日至7日在利斯特希尔礼堂举行。受邀的22名教职员工包括来自NIMH、FDA、NIDA和CDC的公共卫生和政策专家，以及来自美国各地学术中心的领先研究人员和临床医生。听众将包括大约100名来自政府机构、科学家和教育工作者、服务提供商和制药业的代表。在会议的第一天，小组成员将介绍和讨论关键主题的最新研究，如PDE-5使用的流行病学，PDE-5的药理机制和生物行为效应，PDE-5在高危性行为中使用的文化和心理社会模型，在艾滋病毒男性中使用PDE-5的潜在好处和风险，以及社会和政策问题。在会议的第二天，上午将专门举行工作组会议，目的是在研究优先事项、教育优先事项、医疗和安全准则以及法律和伦理影响等领域提出建议。受邀教员将利用下午的时间发表一份共识声明，总结会议的主要发现和结论。会议的两个成果是：1)建议和优先事项的“白皮书”或协商一致声明；2)会议记录，包括所有研究报告、讨论和结论的文件。该项目的关键人员是UMDNJ精神病学和医学教授雷蒙德·C·罗森博士(Raymond C.Rosen)，他将担任PI，以及加州大学旧金山分校艾滋病研究所的约瑟夫·卡塔尼亚(Joseph Catania)博士兼PI。

DESCRIPTION (provided by applicant): The proposed conference will address the potential public health risks presented by PDE-5 use among men with or at risk for HIV infection. Specific issues to be covered are: 1) the association between PDE-5 use and high risk sexual behavior, 2) the relationship between PDE-5 use and the use of illicit drugs, and 3) the prescription of PDE-5s for men who are being treated for other medical problems, including HIV. The conference is planned for May 6-7, 2005, and will be held at the Lister Hill Auditorium. The 22 invited faculty members include public health and policy experts from NIMH, FDA, NIDA, and CDC as well as leading researchers and clinicians from academic centers across the U.S. The audience will include approximately 100 representatives of government agencies, scientists and educators, service providers and the pharmaceutical industry. On the first day of the conference, panel members will present and discuss recent research on key topics such as the epidemiology of PDE-5 use, the pharmacological mechanisms and biobehavioral effects of PDE-5s, cultural and psychosocial models of PDE-5 use in high risk sexual behavior, potential benefits and risks of PDE-5 use among HIV+ men, and societal and policy issues. On the second day of the conference, the morning will be devoted to working group sessions, with the goal of developing recommendations in the areas of research priorities, educational priorities, medical and safety guidelines, and legal and ethical implications. The invited faculty will use the afternoon to produce a consensus statement to summarize the major findings and conclusions of the conference. Two products of the meeting are: 1) a "white paper" or consensus statement of recommendations and priorities, and 2) the meeting proceedings, a document that will include all research presentations, discussions and conclusions. Key personnel for the project are Raymond C. Rosen, Ph.D., Professor of Psychiatry and Medicine at UMDNJ, who will serve as PI, and Joseph Catania, PhD, co-PI, from the AIDS Research Institute at UCSF.