2005 Plant Metabolic Engineering Gordon Res. Conference

描述（由申请人提供）：后基因组时代为操纵植物化学提供了新的机会，这将影响全球食品供应的水平和营养成分，并导致新药物和治疗激素的新生物来源。最近批准的戈登植物代谢工程研究会议（GRC）将为发展多学科合作提供一个环境，这些合作需要揭示植物代谢网络的动态复杂性，并推进植物代谢工程的基础和应用研究。会议将整合基因组学的最新进展，包括代谢物和基因表达分析。研究讨论将探讨生物合成途径如何与底物竞争和通道，生物合成酶的可塑性相互作用，并研究生物合成复合物在原生和非原生环境中的定位，结构和组装。会议将为植物转基因研究开辟新的视角，探讨转基因表达如何影响细胞代谢。将代谢谱分析和通量分析的光谱方法与数学建模相结合，将有助于开发合理的代谢工程策略，并导致新工具的发展，以评估代谢物池的时间和亚细胞变化。会议还将重点介绍途径工程的新技术，包括异种系统的使用，定向酶进化，转录因子工程以及控制生物合成途径的分子/遗传技术的应用。第一次会议将于2005年7月10日至15日在新罕布什尔州蒂尔顿的蒂尔顿学校举行，此后每两年举行一次。演讲者和参与者将有大约130-150人，来自美国和国外的所有职业水平，并代表来自学术界，工业界，私人机构和联邦实验室的机构。将作出协调一致的努力，使妇女、残疾人和来自代表性不足群体的科学家有适当的代表性。

DESCRIPTION (provided by applicant): The post-genomic era presents new opportunities for manipulating plant chemistry that will impact the level and nutritional content of the global food supply and lead to new biological sources of novel drugs and therapeutic hormones. The recently approved new Gordon Research Conference (GRC) on Plant Metabolic Engineering will provide a setting for developing multidisciplinary collaborations needed to unravel the dynamic complexity of plant metabolic networks and advance basic and applied research in plant metabolic engineering. The conference will integrate recent advances in genomics, with metabolite and gene expression analyses. Research discussions will explore how biosynthetic pathways interact with regard to substrate competition and channeling, plasticity of biosynthetic enzymes, and investigate the localization, structure, and assembly of biosynthetic complexes in native and nonnative environments. The conference will develop new perspectives for plant transgenic research with regard to how transgene expression may influence cellular metabolism. Incorporation of spectroscopic approaches for metabolic profiling and flux analysis combined with mathematical modeling will contribute to the development of rational metabolic engineering strategies and lead to the evolvement of new tools to assess temporal and subcellular changes in metabolite pools. The conference will also highlight new technologies for pathway engineering, including use of heterologous systems, directed enzyme evolution, engineering of transcription factors and application of molecular/genetic techniques for controlling biosynthetic pathways. The first conference will take place July 10-15, 2005 at the Tilton School, Tilton, New Hampshire and every two years thereafter. Speakers and participants will number approximately 130-150 from the US and abroad, at all career levels, and represent institutions from academia, industry, private institutes, and federal laboratories. Concerted efforts will be made for appropriate representation by women, persons with disabilities, and scientists from underrepresented groups.