RNA Editing Gordon Research Conference (2005 and 2007)

描述（由申请人提供）：戈登RNA编辑研究会议计划于2005年1月和2007年1月在加州文图拉举行。这个两年一次的会议是唯一定期召开的专门讨论RNA编辑和RNA修饰的会议。术语RNA编辑是指广泛的酶活性，具体改变转录物的初级序列。从机制上讲，有许多不同类型的编辑可以改变基因编码的RNA序列。通过改变转录物的编码能力，RNA编辑可以产生编码具有不同生物学功能的蛋白质的替代mrna。引人注目的是，RNA编辑对于小鼠、蠕虫和苍蝇的神经系统的正常发育和/或功能至关重要。RNA修饰的多样性和程度同样令人惊讶，在所有类型的RNA中报道了近100种不同的核苷。RNA修饰被认为影响许多重要的过程，包括遗传印记、RNA剪接和蛋白质合成的效率或保真度。尽管底物、机制和生物学后果各不相同，但不同类型RNA编辑和修饰的许多关键理论和技术问题是相似的。2005年RNA编辑会议将为研究这些不同过程的科学家提供一个独特的机会，在一次会议上进行互动，以讨论新的假设和机制范例，交换有关实验策略的信息，并启动合作。这次会议将把一个相对较小的科学家小组聚集在一起，在一个非正式的环境中进行为期五天的会议，促进与会者之间的非正式讨论。将邀请该领域的知名领导者以及年轻科学家。讲座将在上午和晚上进行，下午保留非正式讨论，娱乐和海报会议。为了促进编辑和修改社区之间的交流，该计划将以专题会议的形式组织，重点讨论共同感兴趣的问题。

DESCRIPTION (provided by applicant): A Gordon Research Conference on RNA Editing is planned for January 2005 and January 2007 in Ventura, California. This biannual conference is the only regularly scheduled meeting devoted exclusively to RNA editing and RNA modification. The term RNA editing refers to a wide range of enzymatic activities, which specifically alter the primary sequence of a transcript. Mechanistically, there are many different types of editing that alter the sequence of an RNA from that encoded by the gene. By altering the coding capacity of a transcript, RNA editing can generate alternative mRNAs that encode proteins with different biological functions. Strikingly, RNA editing is critical for proper development and/or function of the nervous system in mice, worms, and flies. The variety and extent of RNA modifications are equally astonishing, with almost 100 different nucleosides reported in all types of RNAs. RNA modifications are believed to influence many vital processes, including genetic imprinting, RNA splicing, and the efficiency or fidelity of protein synthesis. Despite the diversity of substrates, mechanisms, and biological consequences, many of the critical theoretical and technical questions for the different types of RNA editing and modification are similar. The 2005 RNA Editing Conference will provide scientists investigating these diverse processes with a unique opportunity to interact at a single meeting in order to discuss new hypotheses and mechanistic paradigms, exchange information about experimental strategies, and initiate collaborations. The meeting will bring together a relatively small group of scientists for five days in a casual setting that fosters informal discussion among participants. Established leaders in the field as well as junior scientists will be invited. Talks will be presented in the mornings and evenings, with the afternoons reserved for informal discussions, recreation, and poster sessions. To promote crossfertilization between the editing and modification communities, the program will be organized in thematic sessions, which will focus on questions of common interest.