Transcriptional Regulation During Cell Growth Differentiation and Development

描述(由申请者提供)：为2006年8月在佛蒙特州萨克斯顿河举行的为期五天的FASE B会议“细胞生长、分化和发育过程中的转录调控”申请部分资金。转录调控是许多控制细胞生长、分化、器官发生和癌症的信号转导和发育途径的最终和关键的终点。了解转录调控的网络和机制对于理解正常的生长发育是必要的，而转录调控失调是许多疾病、发育缺陷和肿瘤转化的基础。这次会议的目的是聚集研究转录基本机制的生物化学家和分子生物学家，研究依赖转录调控的生物过程的细胞和发育生物学家，以及使用全球方法了解参与细胞生长、分化和疾病模型转录调控的相互作用基因网络的科学家。这次FASE B会议在这些领域是独一无二的，因为它不是专注于单一主题，而是将科学家聚集在一起，使用不同的方法来研究不同系统中的转录调控。这种跨学科的方法培养了思考问题的新方法，找到了该领域长期存在的问题的解决方案，也许最重要的是，基础科学和生物医学研究的交叉融合。这次会议还将提供生物学中发展最快的领域之一的最新观点。

DESCRIPTION (provided by applicant): Partial funding is requested for a five day FASEB conference on "Transcriptional Regulation during Cell Growth, Differentiation, and Development" to be held at Saxtons River, Vermont in August 2006. Regulation of transcription is the ultimate and crucial endpoint for many signal transduction and developmental pathways that control cell growth, differentiation, organogenesis, and cancer. Understanding the networks and mechanisms that regulate transcription is necessary to understand normal growth and development, and transcriptional misregulation is the basis for many diseases, developmental defects, and neoplastic transformation. The purpose of this conference is to bring together biochemists and molecular biologists studying fundamental mechanisms of transcription, cell and developmental biologists studying biological processes dependent on transcriptional regulation, and scientists using global approaches to understand networks of interacting genes involved in transcriptional regulation of cell growth, differentiation, and disease models. This FASEB meeting is unique within these fields because rather than focusing on a single topic, it brings together scientists using different approaches to study transcriptional regulation in diverse systems. This interdisciplinary approach fosters new ways of thinking about problems, finding solutions to longstanding questions in the field, and, perhaps most importantly, cross-fertilization of basic science and biomedical research. The conference will also provide an up to date view of one of the most rapidly moving fields in biology.