2006 Gordon Research Conference on Intermediate Filaments

2006年戈登中间长丝研究会议

• 批准号: 7159937
• 负责人: Bishr Omary
• 金额: $ 4.4万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-27 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7159937
• 关键词: intermediate filaments; meeting /conference /symposium; polymerization; travel

DESCRIPTION (provided by applicant): The purpose of this proposal is to generate funds to support travel and/or registration for participants in the 9th Gordon Research Conference on Intermediate Filaments, which will be held July30th-Aug4th, 2006 at Salve Regina University in Rhode Island. Intermediate Filaments (IFs) are major components of the cytoskeleton and nucleoskeleton in higher eukaryotes. In the public draft of the human genome, there are >67 functional genes encoding IF-forming polypeptides. These genes are regulated in a cell-specific manner and are highly conserved in mammalian genomes. A general function of IFs is to endow cells and tissues with mechanical resilience to withstand various types of physical and non-physical stresses. Defects in IF proteins underlie a vast number of genetically determined rare and common disorders involving epithelia (e.g., skin, oral, eye and liver disorders), muscle (e.g., cardiomyopathies; muscular dystrophy), neural tissue (e.g., amyotrophic lateral sclerosis; Alexander disease), lipodystrophies, and premature aging sydromes. IF proteins fulfill other functions in a differentiation and context-dependent fashion, including the response to apoptotic signals, protein targeting to subcellular compartments, cell signaling, subcellular organelle function and nuclear architecture and gene expression. This Gordon Research Conference (GRC) represents the only regular meeting devoted to IF biology. It brings together participants of junior and senior rank from all over the world, who study IF proteins from functional, regulatory, structural, and disease-related perspectives. This GRC has traditionally fostered a free-flowing exchange of novel ideas, tools and reagents, and facilitated the establishment of productive collaborations. The Program for the 2006 edition of the Conference has been finalized and will have a major focus on the broad disease aspect of these proteins, their emerging role in cell signaling and organelle function, the enlarging list of associated proteins they interact with, new structural findings, and potential novel approaches for therapy. The specific sessions that have been scheduled are: 1) Biophysics of IFs; 2) Lamin Biology and Laminopathies; 3) IFs and Organelle Function; 4) Keratin and their Diseases; 5) IFs, Stress and Signaling; 6) Neuronal IF Biology and Diseases; 7) IF Associated Proteins: from Biology to Disease; 8) IFs and Tissue Architecture, and 9) Genomics and Proteomics of IFs.

描述(由申请人提供)： 这项提议的目的是为参加将于2006年7月30日至8月4日在罗德岛州萨尔维里贾纳大学举行的第九届戈登中长丝研究会议的与会者提供旅费和/或登记费用。在高等真核生物中，中间丝是细胞骨架和核骨架的主要组成部分。在公开的人类基因组草图中，有67个功能基因编码IF形成多肽。这些基因是以细胞特有的方式调节的，并且在哺乳动物基因组中高度保守。综合系统的一般功能是赋予细胞和组织机械韧性，以承受各种类型的物理和非物理压力。IF蛋白的缺陷是大量基因决定的罕见和常见疾病的基础，这些疾病涉及上皮(例如皮肤、口腔、眼睛和肝脏疾病)、肌肉(例如心肌病、肌营养不良症)、神经组织(例如肌萎缩侧索硬化症；亚历山大病)、脂肪营养不良和过早衰老综合征。如果蛋白质以分化和上下文依赖的方式完成其他功能，包括对凋亡信号的反应，蛋白质靶向亚细胞间隔，细胞信号，亚细胞细胞器功能和核结构和基因表达。这次戈登研究会议(GRC)代表了唯一一次致力于生物学的定期会议。它汇集了来自世界各地的初级和高级参与者，他们从功能、调节、结构和疾病相关的角度研究IF蛋白质。该GRC传统上促进了新想法、工具和试剂的自由流动交流，并促进了富有成效的合作关系的建立。2006年版会议的计划已经敲定，将主要侧重于这些蛋白质的广泛疾病方面、它们在细胞信号和细胞器功能中的新作用、它们与之相互作用的相关蛋白质的扩大清单、新的结构发现以及潜在的新的治疗方法。已安排的具体会议包括：1)IF的生物物理学；2)板层生物学与椎板病；3)IF与细胞器功能；4)角蛋白及其疾病；5)IF、应激与信号传递；6)神经元IF生物学与疾病；7)IF相关蛋白：从生物学到疾病；8)IF与组织结构；9)IF的基因组学与蛋白质组学。