18th International Congress on Fibrinolysis and Proteolysis

描述(由申请人提供)： 这项提案是为了支持将于2006年8月27日至31日在加利福尼亚州圣地亚哥的圣地亚哥会议中心举行的第18届国际纤溶和蛋白质降解大会：后基因组时代的蛋白质降解。纤溶和胞外蛋白降解的研究是生物医学、临床医学和生物技术交界的一个快速发展的领域。纤溶系统的组成部分在心、肺、脑、肝和肾的疾病中发挥作用，该系统的失衡经常导致血栓形成或出血性疾病。最近出现的数据已经开始阐明纤溶系统的蛋白和其他蛋白酶在正常神经功能和中风发病机制中的关键作用。最近出现的其他数据也证明了该系统在代谢综合征中的关键作用。血栓性疾病，包括心肌梗塞和中风，是美国的主要死亡原因。新的数据还显示，纤溶系统的蛋白水解酶和其他细胞外蛋白水解酶在炎症、癌症、神经系统疾病、传染病、骨质疏松症、肥胖症、激素紊乱、关节炎和衰老中起着关键作用。纤溶酶和其他胞外蛋白水解酶在细胞迁移、血管生成、伤口愈合、纤溶/溶栓、组织重构、发育、血管生物学、血管生成、炎症、细胞迁移、生育、肿瘤侵袭和转移等正常生理过程中的作用日益受到重视。大会的主要目标是推进纤溶和细胞外蛋白分解的研究，促进基础研究与该领域的临床和治疗方面的桥梁和交叉受精，并通过注入可应用于这些研究的最新技术来促进该领域的进步。这将通过强调在理解蛋白酶、受体和调节分子促进疾病和动态平衡的机制方面的最新进展来实现。将重点介绍溶栓治疗的最新发展趋势。将讨论利用蛋白水解酶和蛋白水解酶抑制剂作为治疗剂和治疗靶点的研究。此外，还将介绍蛋白质组学的最新方法和体内动态成像技术的发展。其他主题包括膜锚定蛋白水解酶的功能和细胞外蛋白分解在细胞凋亡中的作用。我们预计将有600名注册人员参加，其中包括在纤溶和蛋白分解的基础和临床方面的知名科学家、新的研究人员和受训人员。预计大会将在溶栓治疗、基于蛋白水解酶的治疗、血管生成、 这些研究涉及动脉粥样硬化、癌症、炎症、神经内分泌功能、肿瘤生物学、传染病、肌营养不良症、激素失调、关节炎和衰老，应该会促进对纤溶和其他细胞外蛋白水解酶在这些过程中的作用的新研究。

DESCRIPTION (provided by applicant): This is a proposal to support the 18 International Congress on Fibrinolysis and Proteolysis: Proteolysis in the Postgenomic Era, to be held August 27-31, 2006, in San Diego, California, in the San Diego Convention Center. The study of fibrinolysis and extracellular proteolysis is a rapidly moving field at the interface of biomedical research, clinical medicine, and biotechnology. The components of the fibrinolytic system play a role in diseases of the heart, lung, brain, liver and kidneys, and imbalances in this system frequently result in either thrombosis or hemorrhagic diatheses. Recent emerging data have begun to elucidate key roles for proteins of the fibrinolytic system and other proteases in normal neurological function and in the pathogenesis of stroke. Other recent data are emerging that document key roles of this system in metabolic syndrome. Thrombotic diseases, including myocardial infarction and stroke, are the leading cause of death in the United States. New data have also revealed that proteases of the fibrinolytic system and other extracellular proteases are key players in inflammation, cancer, neurologic disease, infectious disease, osteoporosis, obesity, hormonal dysfunction, arthritis and aging. The roles of fibrinolytic and other extracellular proteases in the normal physiologic processes of cell migration, angiogenesis, wound healing, apoptosis as fibrinolysis/thrombolysis, tissue remodeling, development, vascular biology, angiogenesis, inflammation, cell migration, fertility, tumor invasion and metastasis are being increasingly recognized. The major objective of the congress is to advance the study of fibrinolysis and extracellular proteolysis and to promote bridging and crossfertilization linking basic studies with clinical and therapeutic aspects of the field and to promote the advancement of the field by infusion of the latest technologies that can be applied to these studies. This will be accomplished by highlighting the most recent developments in understanding the mechanisms by which proteases, receptors and regulatory molecules contribute to disease and homeostasis. The latest trends in thrombolytic therapy will be highlighted. Studies utilizing proteases and protease inhibitors as both therapeutic agents and therapeutic targets will be discussed. In addition, the latest proteomic approaches and developments in in vivo dynamic imaging techniques will be introduced. Other topics to be presented include the function of membrane anchored proteases and the role of extracellular proteolysis in apoptosis. We anticipate attendance of a group of -600 registrants, composed of established scientists, new investigators and trainees in both basic and clinical aspects of fibrinolysis and proteolysis. The congress is expected to provide insights and stimulate new developments in thrombolytic therapy, protease-based therapies, angiogenesis, atherogenesis, cancer, inflammation, neuroendocrine function, tumor biology, infectious disease, muscular dystrophinopathies, hormonal dysfunction, arthritis and aging and should stimulate new research into the roles of fibrinolytic and other extracellular proteases in these processes.