Humane & Efficient Appr. to Develop. Neurotoxicity Test.

描述（由申请人提供） 这次会议是由约翰霍普金斯中心组织的动物试验的替代品。这次会议被称为“创造一个人道和有效的方法来发育神经毒性测试”。 会议将于2006年3月13日至15日在弗吉尼亚州莱斯顿的凯悦酒店举行（靠近华盛顿特区杜莱国际机场）。该会议针对来自美国，欧洲和亚太地区的参与者，他们对发育神经毒性（DNT）的测试方法感兴趣。 研究人员预计将吸引来自工业，政府和学术界的科学研究人员和神经发育毒理学家，以及政策分析师，监管机构，儿童健康和动物福利倡导者。 会议的目标是汇集发育神经毒性测试领域的专家，研究在DNT测试中使用整个动物的替代方法，同时探索有关新方法的验证和监管的政策问题。 预计第一次会议的成果将是：i）对DNT测试的当前实践和未来可能性的理解，以及ii）确定具体任务或活动的行动计划，以帮助推进DNT新测试方法的开发，共享或验证。 这将是CAAT TestSmart DNT计划每18个月举行一次的一系列会议中的第一次。从长远来看，TestSmart DNT计划旨在确定一系列体外和非哺乳动物DNT测试方法，以满足政府要求，增强决策，促进人文科学。 本次会议将涵盖的关键主题包括：发育神经生物学;从儿童健康、动物福利、环境和政府角度的政策整合问题;验证-科学和法规;体外系统和发育神经毒性;替代/非哺乳动物物种（体外模型系统;体外DNT终点;高吞吐量技术和“组学”;鱼、蠕虫、鸟、蝇和其他）;计算毒理学-管理观点;亚太和欧洲对DNT的看法; DNT/新生物学的新前沿。

DESCRIPTION (provided by applicant) This meeting is being organized by the Johns Hopkins Center for Alternatives to Animal Testing. The meeting is called "Creating a Humane and Efficient Approach to Developmental Neurotoxicity Testing". The meeting will take place March 13-15, 2006 at the Hyatt Regency Reston Hotel, Reston, Virginia (close to Washington, DC Dulles International Airport). The meeting is targeted at participants from the USA, Europe and Asia-Pacific who have an interest in methods of testing for developmental neurotoxicity (DNT). The investigators anticipate attracting scientific researchers and neuro-developmental toxicologists from industry, government and academia, as well as policy analysts, regulators, children's health and animal welfare advocates. The goal of the meeting is to bring together experts in the field of developmental neurotoxicity testing to examine alternative methods to the use of whole animals in DNT testing while at the same time exploring the policy issues regarding the validation and regulation of new methods. It is anticipated that the outcome of this first meeting will be: i) an understanding of current practice and future possibilities regarding DNT testing, and ii) an action plan which identifies specific tasks or activities to help take forward the development, sharing, or validation, of new testing methods for DNT. It is intended that this will be the first in a series of meetings which will take place every 18 months as part of CAAT's TestSmart DNT program. Long-term, the TestSmart DNT program is aimed at identifying a battery of in vitro and non-mammalian methods for DNT testing that meets government requirements, enhances decision-making, and promotes humane science. Key topics to be covered in this meeting include: Developmental Neurobiology; Policy Integration Issues from the Perspectives of Children's Health, Animal Welfare, Environment and Government; Validation - Scientific and Regulatory; In Vitro Systems and Developmental Neurotoxicity; Alternative/Non-Mammalian Species (Model Systems In Vitro; Endpoints for DNT In Vitro; High Throughput Technologies and "Omics"; Fish, Worms, Birds, Flies and Others); Computational Toxicology - A Regulatory Perspective; Asia Pacific and European Perspectives on DNT; New Frontiers in DNT/The New Biology.