Humane & Efficient Appr. to Develop. Neurotoxicity Test.

人道

• 批准号: 7114560
• 负责人: Alan M Goldberg
• 金额: $ 1.1万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7114560
• 关键词: developmental neurobiology; meeting /conference /symposium; neurotoxicology; travel

DESCRIPTION (provided by applicant) This meeting is being organized by the Johns Hopkins Center for Alternatives to Animal Testing. The meeting is called "Creating a Humane and Efficient Approach to Developmental Neurotoxicity Testing". The meeting will take place March 13-15, 2006 at the Hyatt Regency Reston Hotel, Reston, Virginia (close to Washington, DC Dulles International Airport). The meeting is targeted at participants from the USA, Europe and Asia-Pacific who have an interest in methods of testing for developmental neurotoxicity (DNT). The investigators anticipate attracting scientific researchers and neuro-developmental toxicologists from industry, government and academia, as well as policy analysts, regulators, children's health and animal welfare advocates. The goal of the meeting is to bring together experts in the field of developmental neurotoxicity testing to examine alternative methods to the use of whole animals in DNT testing while at the same time exploring the policy issues regarding the validation and regulation of new methods. It is anticipated that the outcome of this first meeting will be: i) an understanding of current practice and future possibilities regarding DNT testing, and ii) an action plan which identifies specific tasks or activities to help take forward the development, sharing, or validation, of new testing methods for DNT. It is intended that this will be the first in a series of meetings which will take place every 18 months as part of CAAT's TestSmart DNT program. Long-term, the TestSmart DNT program is aimed at identifying a battery of in vitro and non-mammalian methods for DNT testing that meets government requirements, enhances decision-making, and promotes humane science. Key topics to be covered in this meeting include: Developmental Neurobiology; Policy Integration Issues from the Perspectives of Children's Health, Animal Welfare, Environment and Government; Validation - Scientific and Regulatory; In Vitro Systems and Developmental Neurotoxicity; Alternative/Non-Mammalian Species (Model Systems In Vitro; Endpoints for DNT In Vitro; High Throughput Technologies and "Omics"; Fish, Worms, Birds, Flies and Others); Computational Toxicology - A Regulatory Perspective; Asia Pacific and European Perspectives on DNT; New Frontiers in DNT/The New Biology.

描述(由申请人提供) 这次会议是由约翰·霍普金斯动物试验替代中心组织的。这次会议的题目是“创造一种人道而有效的方法来进行发育神经毒性测试”。会议将于2006年3月13日至15日在弗吉尼亚州雷斯顿凯悦酒店(靠近华盛顿特区杜勒斯国际机场)举行。会议面向来自美国、欧洲和亚太地区的与会者，他们对发育神经毒性(DNT)的测试方法感兴趣。调查人员预计将吸引来自工业、政府和学术界的科学研究人员和神经发育毒物学家，以及政策分析师、监管机构、儿童健康和动物福利倡导者。 会议的目的是聚集发育神经毒性测试领域的专家，研究在DNT测试中使用整个动物的替代方法，同时探讨有关新方法的验证和监管的政策问题。预计第一次会议的结果将是：i)了解关于DNT测试的当前做法和未来的可能性，以及ii)确定具体任务或活动的行动计划，以帮助推进DNT新测试方法的开发、共享或验证。作为CAAT TestSmart DNT计划的一部分，这将是每18个月举行一次的一系列会议中的第一次。从长远来看，TestSmart DNT计划旨在确定一系列用于DNT测试的体外和非哺乳动物方法，以满足政府的要求，提高决策能力，并促进人文科学。 本次会议将讨论的主要议题包括：发育神经生物学；儿童健康、动物福利、环境和政府视角下的政策整合问题；验证-科学和监管；体外系统和发育神经毒性；替代/非哺乳动物物种(体外模型系统；DNT体外终点；高通量技术和“Omics”；鱼、蠕虫、鸟类、苍蝇和其他)；计算毒理学-监管视角；亚太地区和欧洲对DNT的展望；DNT的新前沿/新生物学。