Viral Immunity: From Basic Mechanisms to Vaccines

大多数人类病毒缺乏有效的疫苗，新出现的病毒和在恐怖主义行为中使用外来病毒所造成的问题极其复杂。基础和应用研究的最新进展为了解病毒和免疫系统之间的相互作用提供了前所未有的机会。随着人们越来越多地认识到新出现的病毒，如SARS和“禽流感”，以及病毒作为生物恐怖主义武器的潜在用途，至关重要的是，我们对免疫保护机制的最新了解应充分用于疫苗开发。这次会议将汇集来自学术界，政府和工业界的基础和应用病毒免疫学家， 协同努力，利用最近在了解抗病毒免疫力的产生和长期维持的基本机制方面取得的进展，以制定有效的抗病毒战略。该领域的专家将就病毒免疫学关键领域的最新突破进行全体会议，包括参与免疫启动的分子和免疫细胞，细胞和体液效应机制，以及参与建立和维持保护性记忆反应的机制。讲习班将为讨论前沿成果提供更具互动性的形式。会议的总体重点是讨论如何利用基本概念的进展来制造疫苗。会议的目标是加快现有病毒的疫苗开发，并促进对新出现的病毒和生物恐怖主义的威胁作出快速反应。

Most human viruses lack an effective vaccine, and the problems posed by emerging viruses and the use of exotic viruses in acts of terrorism are extremely complex. Recent advances in basic and applied research have provided an unparalleled opportunity to understand the interplay between the virus and the immune system. With an increasing awareness of newly emerging viruses, such as SARS and "bird-flu", and the potential use of viruses as weapons of bioterrorism, it is essential that recent advances in our understanding of mechanisms involved in immune protection be utilized fully for vaccine development. This meeting will bring together basic and applied viral immunologists from academia, government, and industry to foster collaborative efforts to take advantage of recent progress in understanding basic mechanisms in the generation and long-term maintenance of anti-viral immunity for the development of effective anti-viral strategies. Experts in the field will present plenary talks on the latest breakthroughs in key areas of viral immunology, including molecules and immune cells involved in the initiation of immunity, cellular and humoral effector mechanisms, and mechanisms involved in establishing and maintaining protective memory responses. Workshops will provide a more interactive format for discussion of cutting-edge results. The overall emphasis of the meeting is to discuss how to exploit advances made in fundamental concepts to make vaccines. The goal of the meeting is to accelerate vaccine development for existing viruses, and to facilitate a rapid response to the threat of emerging viruses and bioterrorism.