Genome Sequence Variation

描述（由申请人提供）：常见的人类疾病和大多数其他性状以连续的方式变化，受到多个基因和环境影响的修饰。关于基因组序列变异的信息迅速扩展，这使得人们首次有可能对常见疾病和其他复杂表型的遗传贡献者进行有力的搜索。成功将提供深入了解数量特征的遗传结构，性状变异的进化历史和常见人类疾病的病因。本次会议旨在汇集来自群体遗传学，基因组学，数量遗传学，流行病学和医学研究的研究人员，从各种角度研究这些问题。 大多数常见人类疾病的根本原因仍然未知，我们最有希望的因果关系之一是疾病的家族聚集性。利用来自人类基因组计划、遗传流行病学、数量遗传学和群体遗传学的信息，寻找常见疾病的遗传决定因素越来越实际。通过将这些学科的主要研究人员聚集在一起，这次会议将改进发现疾病遗传因素的方法，从而提高用于改善公共卫生的干预措施的有效性和安全性。

DESCRIPTION (provided by applicant): Common human diseases and most other traits vary in a continuous manner, modified by multiple genes and environmental influences. Rapidly expanding information about genome sequence variation is making it possible for the first time to perform well-powered searches for the inherited contributors to common diseases and other complex phenotypes. Success will provide insight into the genetic architecture of quantitative characteristics, the evolutionary history of trait variation, and the etiology of common human diseases. This meeting aims to bring together investigators from population genetics, genomics, quantitative genetics, epidemiology and medical research to examine these problems from a variety of perspectives. The root causes of most common human diseases remains unknown, with one of our most promising clues to causation being the familial clustering of disease. Leveraging information from the human genome projects, genetic epidemiology, quantitative and population genetics, it is increasingly practical to find the genetic determinants of common diseases. By bringing together leading investigators in each of these disciplines, this meeting will lead to improved methods to discover genetic contributors to disease, which will in turn improve the effectiveness and safety of interventions used to improve public health.