Genome Sequence Variation

描述（由申请人提供）：常见的人类疾病和大多数其他特征以连续的方式变化，受到多种基因和环境影响的修改。关于基因组序列变异的信息迅速扩大，这使得对常见疾病和其他复杂表型的遗传因素进行强有力的搜索首次成为可能。这项研究的成功将有助于深入了解数量特征的遗传结构、性状变异的进化史以及人类常见疾病的病因学。本次会议旨在汇集来自群体遗传学、基因组学、数量遗传学、流行病学和医学研究的研究人员，从不同的角度研究这些问题。

DESCRIPTION (provided by applicant): Common human diseases and most other traits vary in a continuous manner, modified by multiple genes and environmental influences. Rapidly expanding information about genome sequence variation is making it possible for the first time to perform well-powered searches for the inherited contributors to common diseases and other complex phenotypes. Success will provide insight into the genetic architecture of quantitative characteristics, the evolutionary history of trait variation, and the etiology of common human diseases. This meeting aims to bring together investigators from population genetics, genomics, quantitative genetics, epidemiology and medical research to examine these problems from a variety of perspectives. The root causes of most common human diseases remains unknown, with one of our most promising clues to causation being the familial clustering of disease. Leveraging information from the human genome projects, genetic epidemiology, quantitative and population genetics, it is increasingly practical to find the genetic determinants of common diseases. By bringing together leading investigators in each of these disciplines, this meeting will lead to improved methods to discover genetic contributors to disease, which will in turn improve the effectiveness and safety of interventions used to improve public health.