Hereditary Multiple Exostoses: Insights Into Pathogenesis

描述（由申请人提供）：会议的主要目标是建立一个致力于理解和治疗遗传性多发性外生骨疣（HME）的临床和研究社区。这将通过将基础研究人员和整形外科医生，医学遗传学家以及HME家庭聚集在一起来实现。会议将促进所有小组之间的讨论和合作，加速现有知识的整合，并确定具有未来研究潜力的新领域。为期三天的会议将于2005年11月3日、4日、5日在得克萨斯州休斯顿的Shriners儿童医院举行，将有40名与会者参加。其中包括30至35名发言者和5至10名不发言的讨论者。非发言讨论者是HME和骨骼发育和疾病领域的其他专家以及会议共同赞助商MHE联盟的成员。所有与会者将参与整个会议，并将被要求出席所有会议。会议的最后一天将包括个人和家庭与HME谁将被邀请参加。将有7个科学会议，包括：介绍/临床遗传学;医学/骨科考虑; EXT功能/生物化学;非脊椎动物模型;骨发育I;骨发育II;外生骨疣/癌症;非骨表型/EXT样基因;相关骨疾病; HME研讨会。每场会议将有大约三到四位特邀演讲者，他们将进行20分钟的演讲，然后进行10分钟的讨论。我们将鼓励所有发言者就其生物背景和意义概括他们的发现，以便所有与会者都能了解。还鼓励在正式会议之外的用餐期间和下午会议之后进行非正式讨论。希望这些讨论将促进与会者之间新的互动和合作。

DESCRIPTION (provided by applicant): The primary objective of the conference is to establish a clinical and research community devoted to understanding and treating Hereditary Multiple Exostosis (HME). This will be accomplished by bringing together basic researchers and orthopedic physicians, medical geneticists, and families with HME. The meeting will facilitate discussion and collaboration both among and between all groups, accelerating the integration of current knowledge and identifying new areas with future research potential. The three day conference to be held at the Shriners Hospital for Children in Houston, TX is scheduled for November 3, 4, 5, 2005, and will bring together 40 participants. This includes 30-35 speakers and 5-10 non-speaking discussants. The non-speaking discussants are other experts in the field of HME and bone development and disease and members of the MHE Coalition, a co-sponsor of the conference. All conference participants will be involved in the entire conference and will be required to attend all sessions. The last day of the conference will include individuals and families with HME who will be invited to participate. There will be 7 scientific sessions including: Introduction/Clinical Genetics; Medical/Orthopedic considerations; EXT Function/ Biochemistry; Non-vertebrate Models; Bone Development I; Bone Development II; Exostoses/Cancer; Non-bone phenotypes/EXT-like genes; Related Bone diseases; HME Workshop. Each session will have approximately three to four invited speakers who will present 20 minute talks followed by 10 minutes of discussion. We will encourage all speakers to generalize their findings with regard to its biological context and significance so that it will be accessible to all participants. Informal discussion will also be encouraged outside of the formal sessions during meals and after the afternoon sessions. It is hoped that these discussions will promote new interactions and collaborations between participants.