Stem Cells

干细胞

• 批准号: 7192029
• 负责人: CATHERINE M VERFAILLIE
• 金额: $ 0.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7192029
• 关键词: biological signal transduction; cell differentiation; meeting /conference /symposium; stem cells; travel

DESCRIPTION (provided by applicant) Elucidation of self-renewal and commitment pathways that determine stem cell fate are of great interest, both for fundamental biology and for clinical applications in regenerative medicine and cancer therapy. Many efforts are underway to determine cell intrinsic and micro-environmental signals that govern self-renewal and differentiation, and to identify genetic perturbations in these pathways that may result in tumourigenesis. By 2006, progress in unravelling cellular and molecular mechanisms can be expected to begin informing new strategies for clinical intervention. This conference will bring together stem cell biologists in the areas of self renewal and tissue diversification, the stem cell niche, cancer stem cells and cell therapy, to discuss the biological and clinical significance of normal and malignant stem cell function.

说明（由申请人提供）阐明决定干细胞命运的自我更新和承诺途径对于基础生物学和再生医学和癌症治疗的临床应用都具有极大的意义。许多努力正在进行中，以确定控制自我更新和分化的细胞内在和微环境信号，并确定这些途径中可能导致肿瘤发生的遗传扰动。到2006年，细胞和分子机制的研究进展有望开始为临床干预提供新的策略。本次会议将汇集在自我更新和组织多样化，干细胞生态位，癌症干细胞和细胞治疗领域的干细胞生物学家，讨论正常和恶性干细胞功能的生物学和临床意义。