American College of Radiology Imaging Network

美国放射学院影像网络

• 批准号: 7155855
• 负责人: BRUCE J HILLMAN
• 金额: $ 727.91万
• 依托单位: AMERICAN COLLEGE OF RADIOLOGY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-06 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7155855
• 关键词: adult human (21+); bioimaging /biomedical imaging; children; clinical research; clinical trial phase I; cooperative study; diagnosis design /evaluation; disease /disorder prevention /control; early diagnosis; human morbidity; human mortality; human subject; human therapy evaluation; image guided surgery /therapy; imaging /visualization /scanning; magnetic resonance imaging; mass screening; neoplasm /cancer radiodiagnosis; neoplasm /cancer therapy; outcomes research; positron emission tomography

DESCRIPTION (provided by applicant): The American College of Radiology Imaging Network (ACRIN) is a cooperative group dedicated to conducting clinical trials of diagnostic imaging and image-guided therapeutic technologies as they relate to cancer. The overriding goal of ACRIN is to develop information that results in the earlier diagnosis of cancer, allays the concerns of those who do not have cancer, and improves the length and quality of lives of cancer patients. During its initial funding period, ACRIN developed its infrastructure, developed collaborations, and initiated 18 clinical trials. For the proposed funding period, ACRIN intends to conduct trials that address four key hypotheses: i. PET, MRI, and perhaps other functional and metabolic imaging technologies can predict patient response to treatment earlier than conventional anatomic imaging or observing clinical course. ii. Image-guided interventional techniques can locally control the morbidity of cancer and perhaps reduce the mortality. iii. Screening for cancer using imaging technologies can reduce morbidity and mortality. iv. Molecular imaging of metabolic and physiologic processes can improve cancer diagnosis and treatment. In doing so, ACRIN will perform trials of both emerging technologies that could improve cancer care and established technologies where there is the possibility that the technology is being employed inappropriately. ACRIN trials will focus on the cancers which affect the greatest number of individuals, that produce the greatest morbidity and mortality, and that impose the largest financial costs to society.

描述（由申请人提供）：美国放射成像网络学院 (ACRIN) 是一个合作组织，致力于开展与癌症相关的诊断成像和图像引导治疗技术的临床试验。 ACRIN 的首要目标是开发信息，以实现癌症的早期诊断，减轻未患癌症的人的担忧，并提高癌症患者的生活长度和质量。在最初的资助期间，ACRIN 开发了基础设施、开展了合作并启动了 18 项临床试验。在拟议的资助期内，ACRIN 打算进行试验来解决四个关键假设： 我。 PET、MRI 以及其他功能和代谢成像技术可以比传统解剖成像或观察临床病程更早地预测患者对治疗的反应。 二.图像引导介入技术可以局部控制癌症的发病率，并可能降低死亡率。 三.使用成像技术筛查癌症可以降低发病率和死亡率。 四.代谢和生理过程的分子成像可以改善癌症的诊断和治疗。 在此过程中，ACRIN 将试验可以改善癌症护理的新兴技术和可能被不当使用的现有技术。 ACRIN 试验将重点关注影响人数最多、发病率和死亡率最高以及给社会带来最大经济成本的癌症。