St. Louis Breast Cancer Tissue Registry

圣路易斯乳腺癌组织登记处

• 批准号: 7284069
• 负责人: Donald Craig Allred
• 金额: $ 19.84万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7284069
• 关键词: Internet; automated medical record system; biomarker; breast neoplasms; cancer information system; cancer registry /resource; clinical research; cooperative study; data management; female; genetic markers; histopathology; human tissue; immunocytochemistry; information retrieval; microarray technology; neoplasm /cancer classification /staging; prognosis; tissue resource /registry

DESCRIPTION (provided by applicant) The St. Louis Breast Cancer Tissue Registry is one of four institutions that have collaborated for the past 9 years to form the Cooperative Breast Cancer Tissue Resource of the National Cancer Institute. The mission of this group has been the organization, evaluation, maintenance, and distribution of archival breast cancer specimens coupled with detailed data on clinical treatment, outcome, and tumor pathology to facilitate research investigations of new diagnostic and prognostic tumor markers. The significance of tumor marker expression data is greatly enhanced by the extensive case data compiled from cancer registry records, clinical charts, pathology reports, and >5 years patient follow-up for recurrence and vital status. With more than 9000 specimens from 4, geographically and ethnically, diverse regions of the US, the CBCTR provides a unique collection, representative of community medical center patient populations, for evaluation of breast cancer markers that is not readily available to investigators at single medical institutions or biotechnology companies. The combined expertise of the Pl's at the CBCTR institutions include clinical oncology, breast tissue pathology, clinical laboratory operations, clinical trials, and shared resource & cancer research laboratories. Continuing audits of clinical data and tumor classification, development of new tissue screening technologies (tissue microarrays), significant scientific and statistical review of applications for use of the Resource specimens, and moderate service fees further add to the exceptional value of this Resource in the support of many research studies. Over the next 3 year period we will continue to fulfill the responsibilities of a cooperative agreement including 1) work with all members of the CBCTR in a coordinated structure to provide existing tissue and data to researchers, 2) work with all CBCTR members to provide specimens for design and construction of Tissue Microarrays as recommended by the NCI and Research Evaluation Panel (REP), 3) continue to monitor, update, and communicate, with the IMS Central Database, the collection of data linked to our cases, 4) cooperate with all sites, NCI, IMS, and REP members to achieve NCI goals and to publicize this Resource to the cancer research community, and 5) to plan the acquisition and data collection for additional breast cancer tissues, either archival or fresh/frozen, to replenish our finite collection.

描述（由申请人提供） 圣路易斯乳腺癌组织登记处是过去9年来合作组建国家癌症研究所合作乳腺癌组织资源的四个机构之一。该小组的使命是组织、评估、维护和分发乳腺癌档案标本，以及临床治疗、结局和肿瘤病理学的详细数据，以促进新的诊断和预后肿瘤标志物的研究。肿瘤标志物表达数据的重要性通过从癌症登记记录、临床图表、病理学报告和>5年的复发和生命状态的患者随访中汇编的广泛病例数据而大大增强。CBCTR从美国4个地理和种族不同的地区收集了9000多份标本，提供了一个独特的样本集，代表了社区医疗中心的患者人群，用于评估单个医疗机构或生物技术公司的研究人员无法获得的乳腺癌标志物。CBCTR机构的PI的综合专业知识包括临床肿瘤学、乳腺组织病理学、临床实验室操作、临床试验和共享资源&癌症研究实验室。对临床数据和肿瘤分类的持续审计、新组织筛查技术（组织微阵列）的开发、对资源标本使用申请的重要科学和统计审查以及适度的服务费进一步增加了该资源在支持许多研究方面的特殊价值。在接下来的3年里，我们将继续履行合作协议的职责，包括1）与CBCTR的所有成员在协调的结构中合作，为研究人员提供现有的组织和数据，2）与CBCTR的所有成员合作，为NCI和研究评估小组（REP）推荐的组织微阵列的设计和构建提供标本，3）继续监测，更新，并与IMS中央数据库沟通与我们病例相关的数据收集，4）与所有研究中心、NCI、IMS和REP成员合作，以实现NCI目标，并向癌症研究界宣传此资源，以及5）计划其他乳腺癌组织（存档或新鲜/冷冻）的采集和数据收集，以补充我们有限的收集。