3D IMAGING & COMPUTER MODEL OF THE RESPIRATORY TRACT

3D成像

• 批准号: 7118967
• 负责人: RICHARD A CORLEY
• 金额: $ 193.21万
• 依托单位: BATTELLE PACIFIC NORTHWEST LABORATORIES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7118967
• 关键词: Internet; bioimaging /biomedical imaging; clinical research; computer program /software; computer simulation; computer system design /evaluation; fluidity; fluorescence; genetically modified animals; health care personnel education; image processing; laboratory mouse; laboratory rat; magnetic resonance imaging; mathematical model; method development; microcapsule; model design /development; respiratory airflow measurement; respiratory function; respiratory imaging /visualization; statistics /biometry; three dimensional imaging /topography

DESCRIPTION (provided by applicant): The respiratory tract is one of the main interfaces between the body and the environment. Its major structural components are designed to maximize gas exchange and provide sensory input (i.e. odor detection). As such, the respiratory tract can become a target for a broad range of airborne environmental agents contributing to an expansive array of human diseases. Alterations in the structure or function of the respiratory system by diseases can dramatically affect the interface with the environment and alter the quality of life. To improve our ability to predict the dosimetry and thus the consequences of airborne pollutants (gases, vapors, particulates or atmospheric releases of chemical/biological weapons) or drugs intentionally administered by inhalation for normal or potentially sensitive populations, 3-dimensional (3D), biologically based models of the respiratory tracts of animals and humans will be developed by a cross-disciplinary team of mathematicians, physicists, chemists, and biologists. The overall specific aims of this partnership are to: (1) develop and apply magnetic resonance imaging and fluorescent microsphere techniques to determine the dynamic, 3D structural and functional properties of the respiratory tract; (2) determine the 3D cellular organization and metabolic capacity; (3) develop and extend software and computational capabilities for 3D modeling and upscaling techniques for cellular-to-organ model integration; (4) develop a normalized atlas of rat geometries with explicit measures of variability; (5) conduct in vivo gas exchange and particulate dosimetry studies for model validation and identification of model uncertainties; and (6) provide a web-based "pulmonary physiome" platform for dissemination and training of researchers and clinicians in the use of imaging and annotated model databases. Five projects are designed to provide the necessary data on the dynamic structure and function of the respiratory system for the development and validation of the computational models. To support these five projects, three technology development cores will be established in advanced imaging, computation, and database/modeling access and training for external users. A fourth core will serve as an administrative interface and will provide statistical support among the participating institutions and projects.

描述（由申请人提供）： 呼吸道是人体与环境之间的主要界面之一。其主要结构部件旨在最大限度地进行气体交换并提供感官输入（即气味检测）。因此，呼吸道可能成为广泛的空气传播环境因子的目标，这些环境因子导致大量人类疾病。疾病引起的呼吸系统结构或功能的改变会显著影响与环境的界面，并改变生活质量。提高我们预测剂量学的能力，从而预测空气污染物的后果（化学/生物武器的气体、蒸汽、颗粒或大气释放）或药物故意吸入给正常或潜在敏感人群使用，动物和人类呼吸道的三维（3D）生物模型将由数学家、物理学家、化学家和生物学家。这一伙伴关系的总体具体目标是：（1）开发和应用磁共振成像和荧光微球技术，以确定呼吸道的动态、三维结构和功能特性;（2）确定三维细胞组织和代谢能力;（3）开发和扩展用于细胞到器官模型集成的3D建模和升级技术的软件和计算能力;（4）开发具有明确可变性测量的大鼠几何形状的标准化图谱;（5）进行体内气体交换和颗粒剂量测定研究，以验证模型并确定模型的不确定性;以及（6）提供基于网络的“肺生理组”平台，用于传播和培训研究人员和临床医生使用成像和注释模型数据库。五个项目的目的是提供必要的数据的动态结构和功能的呼吸系统的发展和验证的计算模型。为了支持这五个项目，将在高级成像、计算和数据库/建模访问方面建立三个技术开发核心，并为外部用户提供培训。第四个核心将作为一个行政接口，为参与机构和项目提供统计支助。