Multiprojection optical diffusion tomography

多投影光学扩散断层扫描

• 批准号: 7049463
• 负责人: VADIM A MARKEL
• 金额: $ 19.35万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7049463
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; image enhancement; infrared radiation; laboratory mouse; optical tomography

DESCRIPTION (provided by applicant): The Proposal is in the area of optical diffusion tomography (ODT) which is an imaging modality that utilizes near-infrared light for tomographic imaging of biological tissues. Clinical applications of the ODT are currently limited, in part, due to low quality and inadequate spatial resolution of images. The proposed research is aimed at dramatically improving these image characteristics by introducting a novel idea of multiprojection imaging which has not been explored before in the ODT context. It is expected that such improvement will advance the ODT imaging modality closer to possible clinical applications and commercialization. The research will check the following hypothesis: The spatial resolution and noise tolerance of ODT in the slab measurement geometry can be significantly improved by taking several different projections (orientations of the slab with respect to the target). This will be achieved with through the following Specific Aims: Specific Aim 1: To study systematically the influence of multiple projections on spatial resolution and noise tolerance of obtained images in numerical simulations under realistic assumptions about the noise level and the dynamic range and sensitivity of detectors.. Specific Aim 2: To build an ODT imaging device capable of multiple projection measurements and validate the numerical results of the previous Aim for a simple phantom (a small absorbing ball) with optimal experimental parameters. Specific Aim 3: To use the experimental device of the Specific Aim 2 to image a small animal, such as a laboratory mouse.

描述（由申请人提供）： 该提案是在光学扩散断层扫描（ODT）领域，这是一种成像方式，利用近红外光对生物组织进行断层扫描成像。ODT的临床应用目前受到限制，部分原因是图像质量低和空间分辨率不足。所提出的研究旨在通过引入一种新的多投影成像的思想，在ODT的上下文中还没有探索过，从而大大提高这些图像的特性。预计这种改进将推动ODT成像模式更接近可能的临床应用和商业化。该研究将检查以下假设：通过采取几种不同的投影（板相对于目标的方向），可以显着提高空间分辨率和噪声容限的ODT在板测量几何形状。具体目标1：在关于噪声水平、动态范围和探测器灵敏度的现实假设下，在数值模拟中系统地研究多重投影对所获得图像的空间分辨率和噪声容限的影响。具体目标二：建立一个ODT成像设备，能够多个投影测量和验证的数值结果的目的是一个简单的体模（一个小的吸收球）与最佳的实验参数。特定目标3：使用特定目标2的实验装置对小动物（如实验室小鼠）进行成像。