Risk Factors for Venous Thromboembolism in Cancer Patients Receiving Chemotherapy

接受化疗的癌症患者发生静脉血栓栓塞的危险因素

• 批准号: 7194580
• 负责人: ALOK A KHORANA
• 金额: $ 13.07万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-27 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7194580
• 关键词: chemotherapy; clinical research; model; neoplasm /cancer; thromboembolism; thrombosis

DESCRIPTION (provided by applicant): Thromboembolism is a major complication of cancer therapy, particularly with newer agents, and is associated with increased mortality and morbidity in cancer patients. This problem involves disparate fields, and requires an interdisciplinary approach. The objective of this career development award is to provide the applicant, Dr. Alok Khorana, with the experience and knowledge necessary to become an independent clinical investigator in cancer-associated thrombosis. Dr. Khorana will accomplish this objective through the combination of a formal Master's program, directed reading, seminars and mentored research in a supportive institutional environment. A highly qualified and dedicated team of mentors with expertise in thrombosis, cancer and epidemiology, and with a history of training investigators, will supervise this plan and ensure that he achieves his goals. Dr. Khorana will examine risk factors related to the development of venous thromboembolism (VTE) during chemotherapy. The specific aims of this proposal are: 1) to develop and validate a risk model that will identify a group of cancer patients at high risk for development of VTE, 2) to prospectively identify the rate of asymptomatic and symptomatic VTE in a cohort of high-risk patients selected using this model, and 3) to prospectively identify markers of hemostatic and platelet activation that are associated with the development of VTE in this high-risk cohort. The first aim will be accomplished by conducting a secondary analysis of an ongoing prospective observational study, and the latter two aims through a prospective cohort study. Results from the proposed plan will have direct clinical significance by helping identify high-risk patients in a clinical setting. These data will also provide useful information for the design of future trials for prevention of thrombosis. Further, these studies will allow the applicant to enhance his expertise in risk assessment models, design and conduct of clinical trials, and studies of thrombosis. The proposed research plan and mentored career development activities will allow the applicant to develop into" an independent investigator conducting rigorous scientific research. Relevance: Cancer patients on chemotherapy can often develop blood clots, or thrombosis, which can be life-threatening or lead to complications. Thrombosis can be prevented using anticoagulant drugs, but this requires identifying which patients are most at risk. The proposed research plan will develop and test a risk" model to identify such patients, and then enroll high risk patients on a study to be screened during chemotherapy for thrombosis as well as test blood markers that may correlate with its development.

描述（由申请人提供）：血栓栓塞是癌症治疗的主要并发症，特别是使用新药物时，与癌症患者的死亡率和发病率增加相关。这个问题涉及不同的领域，需要跨学科的方法。该职业发展奖的目的是为申请人Alok Khorana博士提供成为癌症相关血栓形成独立临床研究者所需的经验和知识。Khorana博士将通过一个正式的硕士课程，指导阅读，研讨会和指导研究在一个支持性的机构环境的组合来实现这一目标。一支高素质、敬业的导师团队将监督该计划并确保他实现目标，该团队具有血栓形成、癌症和流行病学方面的专业知识，并具有培训调查人员的历史。Khorana博士将研究化疗期间与静脉血栓栓塞（VTE）发展相关的风险因素。这项建议的具体目标是：1）开发和验证一种风险模型，该模型将识别一组具有发生VTE高风险的癌症患者，2）前瞻性地识别使用该模型选择的高风险患者队列中无症状和有症状VTE的发生率，和3）在该高危队列中前瞻性地鉴定与VTE发展相关的止血和血小板活化标志物。第一个目标将通过对正在进行的前瞻性观察性研究进行二次分析来实现，后两个目标将通过前瞻性队列研究来实现。通过帮助识别临床环境中的高风险患者，拟议计划的结果将具有直接的临床意义。这些数据也将为未来预防血栓形成的试验设计提供有用的信息。此外，这些研究将使申请人能够提高其在风险评估模型、临床试验设计和实施以及血栓形成研究方面的专业知识。拟议的研究计划和指导的职业发展活动将使申请人发展成为”一个独立的调查员进行严格的科学研究。相关性：接受化疗的癌症患者通常会出现血栓或血栓形成，这可能危及生命或导致并发症。使用抗凝药物可以预防血栓形成，但这需要确定哪些患者风险最大。拟议的研究计划将开发和测试一个风险模型，以识别这些患者，然后招募高风险患者参加一项研究，在化疗期间筛查血栓形成，并测试可能与其发展相关的血液标志物。