Longitudinal Analysis of Silicone Hydrogel (LASH) Study

硅水凝胶 (LASH) 纵向分析研究

• 批准号: 7047724
• 负责人: LORETTA B SZCZOTKA-FLYNN
• 金额: $ 17.99万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7047724
• 关键词: clinical research; complement pathway regulation; contact lens; cornea; enzyme linked immunosorbent assay; epidemiology; eye disorder diagnosis; eye infections; human subject; hypoxia; immunocytochemistry; inflammation; longitudinal human study; organosilicon compound; patient oriented research; western blottings

DESCRIPTION (provided by applicant): This K23 project serves two purposes: 1) It provides research career development and training for Loretta Szczotka, O.D., M.S., who has made a commitment to focus on patient-oriented research, to launch an independent career in clinical research. 2) It provides her with the knowledge and research skills necessary to translate the findings of previous studies performed by investigators at Case Western Reserve University (CWRU) into the proposed clinical research project, the Longitudinal Analysis of Silicone Hydrogel (LASH) Contact Lens Study. The five-year program, will to lead to 1) the Ph.D. in Epidemiology from the Department of Epidemiology and Biostatistics at CWRU, 2) additional training in the relevant basic and clinical science discipline of ocular immunology, and 3) a better scientific understanding of the factors and mechanisms of inflammatory and mechanical complications of silicone hydrogel continuous wear (CW) contact lens use. The LASH Contact Lens Study, and her training in epidemiology, will allow the candidate to enhance her independent research skills in an area of her clinical expertise, by serving as principal investigator in all phases of the study design, implementation, data management, and data analysis under the guidance of outstanding scientist-mentors in the fields of biometrics, immunology, and ophthalmology. The LASH Contact Lens Study will test the hypothesis that complement activation and regulation coupled with bacterial contamination of lenses and the ocular surfaces are risk factors for contact lens associated inflammatory complications. Additionally, this project will test the hypothesis that novel quantitative central and peripheral corneal shape descriptors, measured by corneal topography, are associated with mechanical complications during long term wear of silicone hydrogel lenses. 224 patients will be enrolled and followed for three years in this longitudinal cohort study.

描述（由申请人提供）：该K23项目有两个目的：1）为Loretta Szczotka，OD提供研究职业发展和培训，医学硕士，世卫组织承诺专注于以患者为导向的研究，在临床研究中开展独立的职业生涯。2)它为她提供了必要的知识和研究技能，将凯斯西储大学（CWRU）的研究人员先前进行的研究结果转化为拟议的临床研究项目，硅水凝胶（LASH）接触透镜研究的纵向分析。五年计划，将导致1）博士学位。CWRU流行病学和生物统计学系的流行病学专业，2）眼部免疫学相关基础和临床科学学科的额外培训，以及3）更好地科学理解硅水凝胶连续配戴（CW）接触镜（透镜）使用的炎症和机械并发症的因素和机制。 LASH接触透镜研究及其流行病学培训将使候选人能够在生物识别、免疫学和眼科学领域的杰出科学家导师的指导下，在研究设计、实施、数据管理和数据分析的所有阶段担任主要研究者，从而提高其在临床专业领域的独立研究技能。 LASH接触透镜研究将检验补体激活和调节以及镜片和眼表细菌污染是接触透镜相关炎症并发症的风险因素的假设。 此外，本项目将检验以下假设：通过角膜地形图测量的新型定量中央和外周角膜形状描述符与长期配戴硅水凝胶镜片期间的机械并发症相关。 本纵向队列研究将入组224例患者并随访3年。