Power Harvesting in Implanted Neural Probes

植入神经探针中的能量收集

• 批准号: 7099376
• 负责人: NITISH VYOMESH THAKOR
• 金额: $ 19.42万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-15 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7099376
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; biosensor device; biotechnology; brain electrical activity; cerebral ischemia /hypoxia; disease /disorder model; glutamates; implant; laboratory rat; medical implant science; microelectrodes; miniature biomedical equipment; monitoring device; neurochemistry; neurophysiology; nitric oxide

DESCRIPTION (provided by applicant): This is an interdisciplinary, innovative technology research and demonstration project to develop the next generation of neural probes for implanted recording. Current neural probes record electrical signals with the use of multiple silicon micromachined electrodes. In an advancement in this field, supported by previous NIH funding, we have demonstrated miniature neurochemical sensors and developed the specialized VLSI integrated circuitry needed to enable chemical measurements from multiple electrodes in a microprobe assembly. The next challenge is to research methods to harvest power to energize the implanted sensor and circuitry. Towards this goal, we propose two innovative technologies 1) the development of a rechargeable, microbattery system capable of sustaining power to the sensor and circuitry, 2) development of a novel VLSI wireless power harvesting circuit to energize the battery. Our other aims are to 3) develop an integrated probe with neurochemical sensor, VLSI wireless interface, power harvesting circuit and microbattery, and 4) evaluate the probe in a model of global ischemic brain injury. This research contributes to our long term goal to build fully implantable, autonomous microprobes, without any tethering, for neurochemical recording in chronically instrumented and tether less animals. A fully self-powered implanted neural microprobe system will be an enabling tool in the hands of neuroscientists interested in recording neural activity from animal models of brain function or brain disorders with the use of microelectrode arrays.

描述(申请人提供)：这是一个跨学科、创新的技术研究和示范项目，旨在开发用于植入记录的下一代神经探头。目前的神经探头使用多个硅微机械电极来记录电信号。在这一领域的进步中，在之前NIH资金的支持下，我们展示了微型神经化学传感器，并开发了专门的VLSI集成电路，使微探针组件中的多个电极能够进行化学测量。下一个挑战是研究收集电力的方法，为植入的传感器和电路提供能量。为了实现这一目标，我们提出了两项创新技术：1)开发一种可充电的微电池系统，能够为传感器和电路供电；2)开发一种新型的VLSI无线电能采集电路，为电池充电。我们的另一个目标是开发一种集成了神经化学传感器、VLSI无线接口、能量采集电路和微电池的探头，以及4)在全脑缺血性脑损伤模型中对该探头进行评估。这项研究有助于我们的长期目标，即在没有任何拴系的情况下，建立完全可植入的、自主的微探针，用于在长期仪器和没有拴系的动物中进行神经化学记录。一个完全自我供电的植入式神经微探针系统将成为神经科学家的一种使能工具，他们有兴趣使用微电极阵列从大脑功能或大脑疾病的动物模型中记录神经活动。