Health - Determining the effect of Salmonella infection on longlived intestinal macrophages and identifying their role in preventing IBD

健康 - 确定沙门氏菌感染对长寿肠道巨噬细胞的影响并确定其在预防 IBD 中的作用

• 批准号: 2672580
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2672580
• 关键词: Health; Determining; effect; Salmonella; infection

Salmonella is a globally significant intestinal infection, causing an estimated 93.8 million cases of gastroenteritis per year. Although usually a self-limiting disease, Salmonella infection can result in increased risk of inflammatory bowel disease (IBD) and colon cancer. The reasons for these post-infection problems are not fully known and further understanding may lead to the development of restorative therapies to prevent these adverse outcomes. Macrophages are known to play a critical role in maintaining gastrointestinal health, contributing to maintaining mucosal barrier integrity and controlling inflammation at this site; dysregulation of these functions are also linked to IBD and colon cancer.

沙门氏菌是一种全球性的肠道感染，估计每年造成9380万例胃肠炎。虽然通常是一种自限性疾病，但沙门氏菌感染可导致炎症性肠病（IBD）和结肠癌的风险增加。这些感染后问题的原因尚不完全清楚，进一步了解可能会导致恢复性治疗的发展，以防止这些不良后果。已知巨噬细胞在维持胃肠道健康方面发挥关键作用，有助于维持粘膜屏障完整性并控制该部位的炎症;这些功能的失调也与IBD和结肠癌有关。