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Unravelling the circuit changes mediating the development of episodic memory

揭示介导情景记忆发展的电路变化

基本信息

批准号：
2673864
负责人：
金额：
--
依托单位：
University of Edinburgh
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2020
资助国家：
英国
起止时间：
2020 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2673864
关键词：
Unravelling circuit changes mediating development

项目摘要

Episodic memory in humans emerges relatively late during juvenile development in comparison to other forms of memory, and is particularly vulnerable to disruption in normal ageing, as well as in neurodevelopmental and neurodegenerative diseases. We have recently found that the ability of rats to show memory in an episodic-like object-place-context (OPC) recognition task also emerges late in juvenile development compared to non-episodic memory tasks. The aim of the PhD project is to identify the circuit changes that mediate the late emergence of episodic memory. The OPC task is known to depend on the integrity of the hippocampus, as well as the lateral entorhinal cortex and medial prefrontal cortex. In this PhD project the student will utilise a combination of behavioural and in vivo electrophysiological recording techniques to characterise the key changes in this circuitry that mediate the emergence of episodic memory in juvenile rats. A second part of the project will be to use a "reverse translation" approach whereby the student will use a behavioural task that has been designed to mimic the OPC task used in the rat studies, to test children of different ages to determine how episodic memory ability develops. Using this approach will enable us to understand more closely how the findings in rats relate to the development of episodic memory abilities in children, allowing for more translational research in the future.

与其他形式的记忆相比，人类的情景记忆在青少年发育期间出现相对较晚，并且特别容易在正常衰老以及神经发育和神经退行性疾病中受到破坏。我们最近发现，大鼠的能力，以显示记忆中的一个情节一样的对象-位置-上下文（OPC）的识别任务也出现在青少年发展的后期相比，非情节记忆任务。博士项目的目的是确定介导情节记忆后期出现的电路变化。已知OPC任务取决于海马体、外侧内嗅皮层和内侧前额叶皮层的完整性。在这个博士项目中，学生将利用行为和体内电生理记录技术的结合来研究介导幼年大鼠情景记忆出现的这种电路的关键变化。该项目的第二部分将使用“反向翻译”方法，即学生将使用一个行为任务，该任务旨在模仿大鼠研究中使用的OPC任务，以测试不同年龄的儿童，以确定情景记忆能力如何发展。使用这种方法将使我们能够更密切地了解大鼠的发现如何与儿童情节记忆能力的发展相关，从而在未来进行更多的转化研究。