Understanding and Exploiting Drug Reactivity with Lipid Membranes.

了解和利用脂质膜的药物反应性。

• 批准号: 2674939
• 金额: --
• 依托单位: Durham University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2674939
• 关键词: Understanding; Exploiting; Drug; Reactivity; Lipid

It has recently become apparent that lipids are reactive towards drugs that partition into membranes. The goals of this project are to understand the extent nature and consequences of this reactivity in biological membranes, and to engineer drugs to exploit this reactivity in order to traverse membrane barriers. The strategies for achieving this is include the synthesis of fatty acids that can taken up into cells and incorporated into membrane lipids to enable the purification and detection of modified drugs, screening of these lipids in relevant cell lines, and the synthesis of modified drugs to induce detectable reactivity. Synthetic fatty acids will also be incorporated into lipids and these lipids characterised in liposomes as model membrane systems.

最近变得明显的是，脂质对分配到膜中的药物具有反应性。该项目的目标是了解这种反应在生物膜中的程度、性质和后果，并设计药物来利用这种反应以穿越膜屏障。实现这一目标的策略包括合成脂肪酸，这些脂肪酸可以被细胞吸收并掺入膜脂质中，以实现修饰药物的纯化和检测，在相关细胞系中筛选这些脂质，以及合成修饰药物以诱导可检测的反应性。合成脂肪酸也将被纳入脂质和脂质体的特点，这些脂质作为模型膜系统。