Developing behavioural methods to assess pain in horses

开发评估马疼痛的行为方法

• 批准号: 2686844
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2025
• 资助国家: 英国
• 起止时间: 2025 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2686844
• 关键词: Developing; behavioural; methods; assess; pain

As of 1st July 2022, Olivia Curry commenced a new PhD project Developing behavioural methods to assess pain in horses under the Supervision of Cathy Dwyer, Juliet Duncan and Gemma Pearson.This studentshi project will look at the causes, risk factors and diagnoses associated with Equine Grass Sickness (EGS), adopting an inter-disciplinary collaborative approach. Both biological and environmental factors will be investigated, with the student having the opportunity to review all available research and using a multi-disciplinary approach, identify gaps in knowledge and undertake relevant research strands to elucidate causal agents and risk factors. Previous research has looked at individual potential causal agents and the lack of success so far in identifying a causative agent suggests it may be multifactorial.The main strands of this research project will include:- Developing a relevant and novel in vitro system comprising 3D gut enteroid cultures from horses to enable the study of the early host-pathogen interactions following challenge of the in vitro cultures with some of the leading candidate causal agents that may be involved in equine grass sickness. - Investigating the use of saliva as a non-invasive test in horses to detect host immune responses to a range of candidate antigens from potential causal agents that may play a role in inducing equine grass sickness. - Samples for the project will be collected in longitudinal studies in selected areas where grass sickness has been prevalent in recent years.- Establishment of a national biobank and database, including questionnaire development, collaborating with vets, horse owners and researchers, to collect biological and environmental samples from EGS cases and controls.

从2022年7月1日起，奥利维亚·科里开始了一个新的博士项目，在凯茜·德怀尔、朱丽叶·邓肯和杰玛·皮尔森的监督下，开发行为方法来评估马的疼痛。该学生项目将采用跨学科合作的方式，研究马草病（EGS）的病因、风险因素和诊断。生物和环境因素都将被调查，学生有机会回顾所有可用的研究，并使用多学科的方法，找出知识上的差距，并进行相关的研究，以阐明因果因素和风险因素。先前的研究着眼于单个潜在的致病因子，迄今为止在确定致病因子方面缺乏成功，这表明它可能是多因素的。该研究项目的主要内容包括：-开发一种相关的新型体外系统，包括来自马的3D肠道样肠培养物，以便在体外培养物受到一些可能与马草病有关的主要候选致病因子的挑战后，研究早期宿主-病原体相互作用。-研究在马中使用唾液作为一种非侵入性测试，以检测宿主对一系列候选抗原的免疫反应，这些抗原来自可能诱发马草病的潜在病原体。-该项目的样本将在近年来草病流行的选定地区进行纵向研究。-建立国家生物库和数据库，包括编制问卷，与兽医、马主和研究人员合作，从EGS病例和对照中收集生物和环境样本。