1st year MSc (Interdisciplinary Biomedical Research). The student will be assigned to a PhD project prior to the 2nd year of study.
第一年理学硕士(跨学科生物医学研究)。
基本信息
- 批准号:2714864
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:英国
- 项目类别:Studentship
- 财政年份:2022
- 资助国家:英国
- 起止时间:2022 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Bacterial resistance to antibiotics is a threat to human health. A lack of effective antibiotics poses a direct threat in the form of an inability to cure life-limiting or life-threatening infections, and also an indirect threat to health because without antibiotics, we could not carry out medical treatments that leave patients with an increased risk of infection (e.g. surgery, transplants, chemotherapy). If we can better understand how bacterial populations evolve resistance to antibiotics - what genetic mutations are involved, how fast resistance arises, whether resistance has any knock-on effects on bacterial susceptibility to other drugs - we will be better positioned to use antibiotics effectively - i.e. to choose the right drugs and the right treatment patterns (how much to prescribe, how often) so it is harder for the bacteria to become resistant. To understand resistance evolution, scientists carry out experiments culturing bacteria over many generations in the presence of antibiotics to see how the population changes. Most of these experiments are carried out in standard laboratory growth media, which are designed to allow bacteria to grow very rapidly rather than being designed to mimic the environments within the body where pathogenic bacteria grow. This is a problem. The different environments at distinct infection sites, such as nutrient availability, oxygen availability, and stress imposed by the host immune system, could all affect how easily resistance evolves, what mutations are naturally selected for, and how resistance changes bacterial physiology. In this project, I will study how bacteria that can infect multiple body sites (P. aeruginosa and E. coli) evolve antibiotic resistance in conditions that mimic infections of the respiratory, urinary tract or wounds. My work will help improve strategies the use of existing antibiotics, and provide ways to test how easily bacteria can evolve resistance to novel antibiotics.
细菌对抗生素的耐药性威胁着人类的健康。缺乏有效的抗生素会造成无法治愈限制生命或威胁生命的感染的直接威胁,也会对健康造成间接威胁,因为没有抗生素,我们就无法进行使患者感染风险增加的医疗治疗(例如手术,移植,化疗)。如果我们能够更好地了解细菌种群如何进化出对抗生素的耐药性-涉及哪些基因突变,耐药性产生的速度有多快,耐药性是否对细菌对其他药物的敏感性产生任何连锁效应-我们将更好地有效使用抗生素-即选择正确的药物和正确的治疗模式(开多少药,多久开一次)所以细菌更难产生耐药性。为了了解耐药性的进化,科学家们进行了实验,在抗生素存在的情况下培养细菌多代,以观察种群如何变化。这些实验大多在标准实验室生长培养基中进行,这些培养基旨在允许细菌非常快速地生长,而不是旨在模拟致病细菌生长的体内环境。这是一个问题。不同感染部位的不同环境,如营养物质的可用性、氧气的可用性和宿主免疫系统施加的压力,都可能影响耐药性进化的容易程度、自然选择的突变以及耐药性如何改变细菌的生理学。在这个项目中,我将研究如何细菌可以感染多个身体部位(铜绿假单胞菌和E。大肠杆菌)在类似呼吸道、泌尿道或伤口感染的条件下进化出抗生素耐药性。我的工作将有助于改进现有抗生素的使用策略,并提供测试细菌如何容易地对新型抗生素产生耐药性的方法。
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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其他文献
Internet-administered, low-intensity cognitive behavioral therapy for parents of children treated for cancer: A feasibility trial (ENGAGE).
针对癌症儿童父母的互联网管理、低强度认知行为疗法:可行性试验 (ENGAGE)。
- DOI:
10.1002/cam4.5377 - 发表时间:
2023-03 - 期刊:
- 影响因子:4
- 作者:
- 通讯作者:
Differences in child and adolescent exposure to unhealthy food and beverage advertising on television in a self-regulatory environment.
在自我监管的环境中,儿童和青少年在电视上接触不健康食品和饮料广告的情况存在差异。
- DOI:
10.1186/s12889-023-15027-w - 发表时间:
2023-03-23 - 期刊:
- 影响因子:4.5
- 作者:
- 通讯作者:
The association between rheumatoid arthritis and reduced estimated cardiorespiratory fitness is mediated by physical symptoms and negative emotions: a cross-sectional study.
类风湿性关节炎与估计心肺健康降低之间的关联是由身体症状和负面情绪介导的:一项横断面研究。
- DOI:
10.1007/s10067-023-06584-x - 发表时间:
2023-07 - 期刊:
- 影响因子:3.4
- 作者:
- 通讯作者:
ElasticBLAST: accelerating sequence search via cloud computing.
ElasticBLAST:通过云计算加速序列搜索。
- DOI:
10.1186/s12859-023-05245-9 - 发表时间:
2023-03-26 - 期刊:
- 影响因子:3
- 作者:
- 通讯作者:
Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly.
使用通过嵌段共聚物自组装制造的 2D 金纳米结构阵列放大 EQCM-D 检测细胞外囊泡。
- DOI:
10.1039/d2nh00424k - 发表时间:
2023-03-27 - 期刊:
- 影响因子:9.7
- 作者:
- 通讯作者:
的其他文献
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{{ truncateString('', 18)}}的其他基金
An implantable biosensor microsystem for real-time measurement of circulating biomarkers
用于实时测量循环生物标志物的植入式生物传感器微系统
- 批准号:
2901954 - 财政年份:2028
- 资助金额:
-- - 项目类别:
Studentship
Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
利用人类肠道微生物群的多糖分解能力来开发环境可持续的洗碗解决方案
- 批准号:
2896097 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
A Robot that Swims Through Granular Materials
可以在颗粒材料中游动的机器人
- 批准号:
2780268 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Likelihood and impact of severe space weather events on the resilience of nuclear power and safeguards monitoring.
严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
- 批准号:
2908918 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Proton, alpha and gamma irradiation assisted stress corrosion cracking: understanding the fuel-stainless steel interface
质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
- 批准号:
2908693 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
- 批准号:
2908917 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
- 批准号:
2879438 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
- 批准号:
2890513 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
了解野生鸟类肠道微生物组、行为和城市化之间的相互作用
- 批准号:
2876993 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
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