Sympathetic Nervous System & Metabolism in Older Humans

描述（由申请人提供）：候选人-候选人，克里斯托弗贝尔博士，是一位生理学家，目前由美国心脏协会的博士后个人奖学金支持。贝尔博士过去和现在的研究重点是生理老化对休息和运动能量消耗的影响。他的近期目标是获得新的研究和专业技能，以帮助他实现他的长期目标，发展一个成功的独立的外部资助的研究计划在老龄化。拟议的K 01开发计划应向Bell博士提供必要的培训，以实现其目标。 贝尔的拟议研究职业发展活动包括：1）获得与拟议的研究计划相关和补充的新的研究技能;和2）结构化的活动，包括正式的课程工作;在期刊俱乐部，系列研讨会和科学会议的出席和演讲;和他的指导团队定期互动。总体计划以“转化研究”培训模式为基础。 环境-贝尔博士的研究培训环境应该是杰出的。赞助者，道格拉斯西尔斯博士，是一个很好的建立在校外资助的科学家与一个强大的记录，成功的指导在生物医学老化研究。他还得到几名顾问的协助，他们将在培训计划的具体领域提供指导。老龄化研究的其他教师增强了当地的培训环境。 研究-本研究的总体目的是增加我们对β-肾上腺素能受体交感神经系统（β-AR SNS）调节静息代谢率（RMR）变化的机制的理解，以及成年人衰老时的产热作用。我将确定能量通量（能量平衡时的饮食摄入和能量消耗水平）、β-AR反应性增加和β 2-AR基因变异对中老年人RMR和产热的β-AR SNS支持的影响。

DESCRIPTION (provided by applicant): Candidate - The candidate, Christopher Bell, Ph.D., is a physiologist currently supported by an individual postdoctoral fellowship from the American Heart Association. Dr. Bell's past and current research focus has been on the effect of physiological aging on resting and exercise energy expenditure. His immediate goal is to acquire new research and professional skills to help him achieve his long-term goal of developing a successful independent extramurally-funded research program in aging. The proposed K01 development plan should provide Dr. Bell with the necessary training to achieve his goal. Career Development Plan - Dr. Bell's proposed research career development activities consist of: 1) acquiring new research skills associated with and complementary to the proposed research plan; and 2) structured activities including formal course work; attendance and presentation at journal clubs, seminar series, and scientific meetings; and regular interactions with his mentoring team. The overall plan is based on a "translational research" training model. Environment - The environment for Dr. Bell's research training should be outstanding. The sponsor, Dr. Douglas Seals, is a well-established extramurally-funded scientist with a strong record of successful mentoring in biomedical aging research. He is complemented by several consulting mentors who will provide guidance in specific areas of the training plan. Other faculty in aging research enhances the local training environment. Research - The general aim of this research is to increase our understanding of the mechanisms responsible for changes in beta-adrenergic receptor sympathetic nervous system (beta-AR SNS) modulation of resting metabolic rate (RMR) and thermogenesis with aging in adult humans. I will determine the influence of energy flux (the level of dietary intake and energy expenditure while in energy balance), increased beta-AR responsiveness, and beta2-AR gene variants on beta-AR SNS support of RMR and thermogenesis in middle-aged and older adult humans.