Neuronal connectivity underlying color vision

色觉的神经元连接

• 批准号: 7007321
• 负责人: Daniel Vasiliauskas
• 金额: $ 4.99万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7007321
• 关键词: Drosophilidae; color visions; developmental neurobiology; eye; gene expression; genetic mapping; green fluorescent proteins; neurons; postdoctoral investigator; retina; visual perception; visual photoreceptor

DESCRIPTION (provided by candidate): Color vision requires a comparison of outputs from different types of color photoreceptor cells. In vertebrates, the initial steps of this processing are performed by retinal neurons that connect to the color photoreceptors. In fruit flies, such connections are likely to occur in the medulla, a brain structure close to the fly retina. In principle, a number of different comparisons could be made between four different types of fly color photoreceptors. We plan to identify neurons which contact two or more different types of photoreceptors. This, together with our knowledge of photoreceptor properties, will provide a better understanding of the mechanisms of color processing in flies. We expect that the basic principles that we will uncover will apply to color vision in different animals, including humans. To this end, we propose to develop three different approaches for visualizing neurons connected to the photoreceptors: by randomly labeling different sets of neurons, by identifying markers for specific sets of medulla neurons and by directly labeling neurons connected to the color photoreceptors. Our work will provide a solid foundation for further studies involving genetic manipulations of color-processing neurons and further understanding of color perception .

描述（由候选人提供）：色觉需要比较不同类型的彩色感光细胞的输出。 在脊椎动物中，这种处理的最初步骤是由连接到彩色光感受器的视网膜神经元执行的。 在果蝇中，这种连接很可能发生在髓质中，这是一种靠近果蝇视网膜的大脑结构。 原则上，可以在四种不同类型的苍蝇颜色光感受器之间进行许多不同的比较。 我们计划识别与两种或更多种不同类型的光感受器接触的神经元。 这一点，加上我们的感光特性的知识，将提供一个更好地了解苍蝇的颜色处理的机制。 我们希望我们将发现的基本原理将适用于不同动物的色觉，包括人类。 为此，我们建议开发三种不同的方法来可视化连接到光感受器的神经元：通过随机标记不同的神经元集合，通过识别特定的髓质神经元集合的标记，以及通过直接标记连接到彩色光感受器的神经元。 我们的工作将提供一个坚实的基础，进一步研究涉及颜色处理神经元的遗传操作和进一步了解颜色感知。