Substance P and the tectothalamic pathway

P 物质和盖丘脑通路

• 批准号: 7056280
• 负责人: Sean P Masterson
• 金额: $ 2.55万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7056280
• 关键词: attention; electron microscopy; electrophysiology; gamma aminobutyrate; glutamates; immunocytochemistry; interneurons; laboratory rat; neural information processing; neuroanatomy; neuropeptide receptor; neuroregulation; predoctoral investigator; pulvinar thalami; receptor expression; substance P; superior colliculus; synapses; thalamic nuclei; thalamus; visual cortex; visual pathways; voltage /patch clamp

DESCRIPTION (provided by applicant): The long term goal of the proposed experiments is to determine the causes of attention impairment during disease. However, it is first necessary to understand the organization of circuits that may contribute to attention mechanisms in the normal brain. Many studies have implicated the pulvinar nucleus as an area that may regulate visual attention. The rodent lateral posterior (LP) nucleus is a region comparable to inferior regions of the primate pulvinar nucleus. The rodent LP nucleus is innervated by fibers which contain the neuropeptide substance P, a neuromodulator known to facilitate neuronal firing properties. The LP nucleus receives visual input from projection cells within an area of the superior colliculus that is substance P- immunoreactive. A combination of tract tracing, immunocytochemistry, electron microscopy and in vitro electrophysiology will be used to examine the synaptic organization and functional properties of the tecto- thalamic pathway. Concomitant release of substance P with glutamate from tecto-thalamic terminals might enhance and potentiate glutamatergic input from the superior colliculus. Because the LP nucleus projects to the visual cortex, the tecto-thalamic pathway could affect visual attention by modulating cortical circuitry.

描述（由申请人提供）：拟议实验的长期目标是确定疾病期间注意力受损的原因。然而，首先有必要了解正常大脑中可能有助于注意力机制的回路的组织。许多研究表明枕核可能是调节视觉注意力的区域。啮齿类动物的外侧后核（LP）是一个可与灵长类动物枕核的下部区域相媲美的区域。啮齿动物LP核由含有神经肽物质P的纤维支配，P是一种已知促进神经元放电特性的神经调质。LP核接收来自上级丘内P物质免疫反应性区域内投射细胞的视觉输入。将使用束示踪、免疫细胞化学、电子显微镜和体外电生理学的组合来检查顶盖-丘脑通路的突触组织和功能特性。顶盖-丘脑末梢同时释放P物质和谷氨酸可能增强和加强上级丘的谷氨酸能输入。由于LP核投射到视觉皮层，顶盖-丘脑通路可以通过调节皮层回路来影响视觉注意。