Behavioral Genetic Analysis of Inhibitory Control

描述（由申请人提供）：拟议研究的主要目标是评估遗传和环境影响对儿童早期抑制控制（IC）的作用。在拟议的调查，200对双胞胎将在2岁的IC和相关行为进行评估，在实验室的情况。将获得父母对IC、行为问题和其他气质维度的评分，观察者对IC和其他气质维度的评分，以及认知能力的测量。关于IC的发展和相关行为知之甚少。大多数IC研究者认为IC出现在2岁，然而，由于方法论的原因，相对较少有人研究这个重要的年龄。IC在精神病理学发展中的重要性，以及与气质的其他维度的结合也是一个重要的考虑因素。进一步的研究只能用于完善IC的病因，以及它如何有助于儿童期和整个生命周期的气质，认知和精神病理学的发展。除了发现与这些行为相关的特定基因的可能性之外，对遗传和环境贡献的探索可能有助于预测有发育困难风险的个人或群体。

DESCRIPTION (provided by applicant): The main goal of the proposed research is to assess the role of genetic and environmental influences on inhibitory control (IC) in early childhood. In the proposed investigation, 200 twin pairs will be assessed for IC and related behaviors at 2 years of age in a laboratory situation. Parent ratings of IC, behavior problems, and other temperament dimensions, observer ratings of IC and other temperament dimensions, and a measure of cognitive ability, will be obtained. Little is known about the development of IC and related behaviors. Most IC researchers posit that IC emerges at the age of two, however, relatively few have studied it at this important age for methodological reasons. IC's importance in the development of psychopathology, as well as in conjunction with other dimensions of temperament is also an important consideration. Further research can only serve to refine the etiology of IC, and how it contributes to the development of temperament, cognition, and psychopathology in childhood and across the lifespan. The exploration of genetic and environmental contributions, in addition to the possibility of discovering specific genes related to these behaviors, may help predict individuals or groups at risk for developmental difficulties.