Consolidation of Trace Fear in Hippocampus and Amygdala

海马体和杏仁核中微量恐惧的巩固

• 批准号: 7026469
• 负责人: MARIEKE R GILMARTIN
• 金额: $ 2.68万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7026469
• 关键词: amygdala; auditory stimulus; behavior test; behavioral /social science research tag; conditioning; electrodes; electrostimulus; fear; hippocampus; laboratory rat; learning; memory; predoctoral investigator; psychometrics; sound perception; statistics /biometry

Auditory trace fear conditioning requires animals to associate a tone conditioned stimulus and ia shock unconditioned stimulus that are separated by an empty 20-second trace interval. This learning task is dependent upon both the hippocampus and the amygdala, which are two of the most important structures in learning and memory. These structures have been studied extensively, but relatively few studies have examined how the hippocampus and amygdala interact. Recently, a process known as reconsolidation has been described where established memories can be lost if protein synthesis is inhibited immediately after the memory is recalled. It is not known, however, whether simultaneously acquired memories are recalled independently of one another or if the recall of one memory reactivates multiple related memories. Understanding how multiple memories are recalled and reconsolidated would provide insights into how neurodegenerative processes, such as natural aging and Alzheimer's disease, could disrupt established memories. This proposal will examine the roles of the hippocampus and amygdala in the consolidation of trace and contextual fear memories and determine if these simultaneously acquired memories can be recalled and disrupted independently of one another. This proposal will also determine if these two important structures have differential roles in encoding information about trace fear conditioning.

听觉痕迹恐惧条件反射要求动物将音调条件刺激和 IA电击无条件刺激，由20秒的空白轨迹间隔隔开。这个学习任务依赖于海马体和杏仁核，这是学习和记忆中最重要的两个结构。这些结构已经得到了广泛的研究，但相对较少的研究探讨了海马体和杏仁核是如何相互作用的。最近，一种被称为重新巩固的过程被描述，在这种过程中，如果记忆被召回后，蛋白质合成立即被抑制，那么已经建立的记忆可能会丢失。然而，目前尚不清楚同时获得的记忆是否被彼此独立地回忆起来，或者一个记忆的回忆是否重新激活了多个相关的记忆。了解多个记忆是如何被回忆和重新整合的，将有助于我们深入了解 神经退化过程，如自然衰老和阿尔茨海默病，可能会扰乱已建立的记忆。这项提议将研究海马体和杏仁核在巩固痕迹和背景恐惧记忆中的作用，并确定这些同时获得的记忆是否可以相互独立地回忆和破坏。这一建议还将确定这两种重要结构在编码有关痕迹恐惧条件反射的信息方面是否具有不同的作用。