A Shear Modulus Imager

剪切模量成像仪

• 批准号: 6882941
• 负责人: WALTER G SCOTT
• 金额: $ 9.89万
• 依托单位: WINPROBE CORPORATION
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6882941
• 关键词: breast neoplasm /cancer diagnosis; computer program /software; data collection methodology /evaluation; diagnosis design /evaluation; diagnosis quality /standard; image enhancement; image processing; mathematical model; model design /development; molecular /cellular imaging; phantom model; time resolved data

DESCRIPTION (provided by applicant): WinProbe Corporation proposes research into implementing real-time elastography methods of ultrasonic imaging aimed at improving the diagnosis of breast cancer in an optimized Research Platform. Elastography has been the subject of intense research for at least twenty years yet only minimal commercial offerings have materialized. The practical issue of providing enough computational power intimately connected to the RF-data stream of the transducer, to produce the required complex real time calculations, has been challenging and not yet fully attained. WinProbe is proposing the introduction of a very powerful computational ultrasound system to this field and to convert the work of several eminent researchers of elastography to a practical imaging mode. Several of these researchers have also been enlisted in this project's team. It is thus proposed to advance the knowledge base through to a practical clinical method and instrument. Significant prior research exists that reports success in discriminating cancerous lesions from normal tissue by these methods in retrospective computations. One primary objective of this project is to investigate the use of Acoustic Radiation Force Pushes and their subsequently generated shear waves, in combination with real-time static elastography produced by manually applied pre-compression loads. The modulus and the rate of change of modulus with respect to strain will be quantitatively estimated, and the results mapped in real-time in color overlays of a live real-time B-Scan image. Demonstration of the methods instantiated into the hardware is presented as the milestones for Phase I. Testing, evaluation, optimizing and in vivo studies are proposed for Phase II. The following are tasks to be performed in Phase I:  Transducer stress measurement by incorporation of load cells into a transducer and the associated software program for operator feedback and automatic triggers for data acquisition,  Algorithm instantiation for real-time static elastography,  Algorithm instantiation for Acoustic Radiation Force Push with modeling and verification,  Algorithm instantiation for estimation of shear displacement at the focal point of the ARF-Push,  Algorithm investigation for modulus estimation by tracking shear wave propagation,  Design and construction of phantoms mimicking differing moduli of cancer lesions and normal tissue for the evaluation of the algorithms above.

描述（由申请人提供）：WinProbe公司提出了一项研究，旨在通过优化的研究平台实现超声成像的实时弹性成像方法，以提高乳腺癌的诊断。弹性成像技术已经进行了至少20年的深入研究，但只有很少的商业产品已经实现。提供与换能器的射频数据流密切相关的足够计算能力以产生所需的复杂实时计算的实际问题一直具有挑战性，并且尚未完全实现。WinProbe正在提议将一个非常强大的计算超声系统引入该领域，并将几位杰出的弹性成像研究人员的工作转化为实用的成像模式。其中一些研究人员也加入了这个项目的团队。因此，建议将知识库提升为实用的临床方法和仪器。重要的先前研究存在，报告成功地区分癌病变从正常组织通过这些方法在回顾性计算。该项目的一个主要目标是研究声辐射力推力及其随后产生的剪切波的使用，并结合人工施加预压缩载荷产生的实时静态弹性。模量和模量相对于应变的变化率将被定量估计，并将结果实时映射到实时b扫描图像的彩色叠加中。硬件实例化方法的演示作为第一阶段的里程碑。第二阶段建议进行测试、评估、优化和体内研究。以下是第一阶段须执行的工作：传感器应力测量，将测压元件集成到传感器中，用于操作员反馈和数据采集的相关软件程序，实时静态弹性学算法实例，声辐射力推力建模和验证算法实例，估计ARF-Push焦点剪切位移的算法实例，基于横波传播跟踪的模量估计算法研究