UK Spinal Cord & Brain Injury Research Center Core Grant

描述（由申请人提供）： 本申请是响应NINDS计划公告，要求机构中心核心赠款支持神经科学研究。因此，目前的申请旨在创建英国脊髓和脑损伤研究中心（SCoBIRC）核心补助金，以加速10名NINDS资助的研究人员的研究项目，这些研究人员目前是12名NINDS R 01的Pis，并加强。该应用程序要求支持五个核心设施：行政和生物信息学核心，动物外科和TBI/SCI模型核心，行为测试核心，显微镜，图像分析和体视学核心以及药代动力学和生物标志物核心。虽然一些拟议的技术目前已在个别调查人员的实验室中就位，但目前没有任何核心。提议将这些资源集中起来，在某些情况下升级并增加设备。每个核心都需要专门的技术支持，以确保它们在最小的停机时间和设备故障的情况下有效运行，并有助于提高SCoBIRC和其他NINDS支持的调查人员的生产力。预计这些核心还将促进数据交流和促进全面合作。所有参与的研究者都记录了使用大多数核心设施的需求：10名研究者中有6名将使用所有5个核心设施，3名将使用4个核心设施，只有1名将使用3个核心设施。核心数据的使用将与其他不合格的神经学研究者共享。PI具有丰富的管理经验，每个核心董事都完全有资格指导拟议技术的使用。在5个案件中的4个案件中，他们将得到同样有经验的助理主任和专职技术人员的支持，他们将进行试点研究，培训新的调查员，处理时间安排，维持用品和设备维修。由所有合格调查员组成的指导委员会将每季度审查核心调查员的业绩。预计这些核心的存在将极大地促进SCoBIRC使命的完成，该使命旨在发现和临床转化脊髓和脑损伤的治疗方法。此外，这些设施将提供集中的技术，这将有利于英国的神经学研究，并提高有经验的和年轻的研究人员竞争校外资金的能力。

DESCRIPTION (provided by applicant): This application is in response to the NINDS Program Announcement requesting institutional center core grants to support neuroscience research. Accordingly, the current application seeks to create the UK Spinal Cord & Brain Injury Research Center (SCoBIRC) Core Grant to accelerate the research projects of 10 NINDS-funded investigators who are currently Pis on 12 NINDS R01s, and to enhance . The application asks for support for five core facilities: an Administrative and Bioinformatics Core, an Animal Surgery & TBI/SCI Model Core, a Behavioral Testing Core, a Microscopy, Image Analysis & Stereology Core and a Pharmacokinetics and Biomarker Core. Although some of the proposed technologies are currently in place in the laboratories of individual investigators, none of the cores currently exists. The proposal is for these resources to be centralized, in some cases upgraded and added to with additional equipment. Dedicated technical support is requested for each of the cores to insure that they will be run efficiently with minimal downtime and equipment failure, and serve to enhance the productivity of SCoBIRC and other NINDS-supported investigators. It is also expected that these cores will promote communication of data and foster overall collaboration. All of the participating investigators have documented needs for the use of most of the core facilities: 6 of 10 will use all 5 cores, 3 will use 4 of the cores and only 1 will use 3 of them. Use of the cores will be shared with other non-qualifying neurological investigators. The PI has had considerable administrative experience, and each of the Core Directors is fully qualified to direct the use of the proposed technologies. They will be backed up in 4 of the 5 cases with equally experienced Assistant Directors and dedicated technical staff who will perform pilot studies, train new investigators, handle scheduling, maintain supplies and equipment maintenance. The performance of the cores will be reviewed quarterly by a Steering Committee consisting of all of the qualifying investigators. It is anticipated that the existence of these cores will greatly enhance the accomplishment of the SCoBIRC mission which is directed at the discovery and clinical translation of therapeutic approaches for spinal cord and brain injury. In addition, these facilities will make available centralized technologies which will benefit UK neurological research in general, and improve the ability of both experienced and young investigators to compete for extramural funding.