Child and Adolescent Psychiatry Trials Network (CAPTN)

儿童和青少年精神病学试验网络 (CAPTN)

• 批准号: 7127619
• 负责人: JOHN S MARCH
• 金额: $ 160.8万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-16 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7127619
• 关键词: adolescence (12-20); child mental disorders; clinical research; clinical trials; interdisciplinary collaboration

DESCRIPTION (provided by applicant): Responding to PAR-01-089 for Advanced Centers for Interventions and Services Research (ACISR), the Duke Clinical Research Institute (DCRI) in concert with the American Academy of Child and Adolescent Psychiatry (AACAP) propose to develop an innovative large, simple "pragmatic" trials network, the Child and Adolescent Psychiatry Trials Network (CAPTN). The overall goal of CAPTN is to provide reliable estimates of mental health outcomes applicable to a broad patient base treated under usual clinical conditions without bias. Guided by CAPTN participants and a Steering Committee representing the major stakeholders in the field, we take as our starting place two critically important clinical issues: (1) widely used single and combined drug treatments for which randomized evidence is absent and (2) the long-term safety of mono and polypharmacy. CAPTN will operate as a Center within the DCRI, an experienced academic research organization with extensive experience in clinical trials coordination. Four Cores are proposed: The Operations Core provides overall administrative leadership, project management, site management, data management, and statistical services, as well as administrative oversight of the career development and clinical research training program. The Methods Core selects the questions to be addressed and provides expertise in research design, clinical trial methodology, practice research, clinical assessment, bioinformatics, and data analytic techniques. The Trials Core focuses on the development of specific trials to be conducted by the Network. Working with the AACAP, the Network Core provides for the development and expansion of the network. With 200 to 400 child and adolescent psychiatrists each participating in two to four randomized controlled trials per year, CAPTN enacts recommendations of the Clinical Treatment and Services Research Workgroup of the National Advisory Mental Health Council (NAMHC) to develop "strategies for increasing the relevance, speeding the development, and facilitating the utilization of research-based treatment and service interventions for mental illnesses into both routine clinical practice and policies guiding our local and national mental health service systems."

描述（由申请人提供）：响应PAR-01-089高级干预和服务研究中心（ACISR），杜克临床研究所（DCRI）与美国儿童和青少年精神病学学会（AACAP）合作，提议开发一个创新的大型、简单的“务实”试验网络，即儿童和青少年精神病学试验网络（CAPTN）。CAPTN的总体目标是提供适用于在常规临床条件下接受治疗的广泛患者基础的心理健康结局的可靠估计，无偏倚。在CAPTN参与者和代表该领域主要利益相关者的指导委员会的指导下，我们将两个至关重要的临床问题作为出发点：（1）广泛使用的单一和联合药物治疗，缺乏随机证据;（2）单药和多药的长期安全性。CAPTN将作为DCRI内的一个中心运营，DCRI是一个经验丰富的学术研究组织，在临床试验协调方面拥有丰富的经验。提出了四个核心：运营核心提供全面的行政领导、项目管理、研究中心管理、数据管理和统计服务，以及对职业发展和临床研究培训计划的行政监督。方法核心选择要解决的问题，并提供研究设计，临床试验方法，实践研究，临床评估，生物信息学和数据分析技术方面的专业知识。审判核心侧重于制定将由该网络进行的具体审判。网络核心与AACAP合作，为网络的发展和扩展提供支持。每年有200至400名儿童和青少年精神病医生参加2至4项随机对照试验，CAPTN制定了国家心理健康咨询理事会（NAMHC）临床治疗和服务研究工作组的建议，以制定“增加相关性，加速发展，促进将基于研究的精神疾病治疗和服务干预纳入常规临床实践和指导我们地方和国家精神卫生服务体系的政策。"