Catalytic alkane C-H borylation + retro-hydroboration: towards a lower energy route to convert alkanes into terminal olefins

催化烷烃C-H硼基化逆硼氢化：采用较低能量的路线将烷烃转化为末端烯烃

• 批准号: 2735121
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2735121
• 关键词: Catalytic; alkane; borylation; retro; hydroboration

Alkane upgrading is a major industrial goal (for biomass, waste and fossil fuel derived alkanes) that can drastically enhance the efficiency of the chemical industry. In phase 1 of this proof of concept study we aim to demonstrate that Earth-abundant electrophilic metal catalysts can activate hydroboranes to perform sp3 C-H borylation to generate alkylboranes. While alkylboranes are useful in their own right as versatile synthetic intermediates, phase 2 of this project will look at one specific application of alkylboranes - the thermal conversion of alkylboranes to alkenes by dehydroboration (a process that regenerates the hydroborane for potential use in phase 1). Success would establish the feasibility of a low energy route (relative to commercialised direct alkane dehydrogenation currently performed on a large scale) to convert alkanes to terminal alkenes which is a significant and currently unmet challenge in the chemical industry.

烷烃升级是一个主要的工业目标（对于生物质、废物和化石燃料衍生的烷烃），可以大大提高化学工业的效率。在概念验证研究的第一阶段，我们的目标是证明地球上丰富的亲电子金属催化剂可以激活氢硼烷进行 sp3 C-H 硼基化以生成烷基硼烷。虽然烷基硼烷本身可用作多功能合成中间体，但该项目的第二阶段将着眼于烷基硼烷的一个具体应用 - 通过脱硼氢反应将烷基硼烷热转化为烯烃（一种再生氢硼烷以供第一阶段使用的过程）。成功将确立低能量路线（相对于目前大规模进行的商业化直接烷烃脱氢）将烷烃转化为末端烯烃的可行性，这是化学工业中目前尚未解决的重大挑战。