he impact of air pollution on host-pathogen interactions.

空气污染是世界上最大的单一环境健康风险，每年造成全球八分之一的死亡（世界卫生组织，2017）。颗粒物（PM）是空气污染的关键成分，与慢性呼吸道疾病（如COPD和哮喘）以及社区获得性肺炎、感染性心内膜炎、囊性纤维化患者的感染、中耳炎和慢性鼻窦炎的恶化密切相关。先前的工作已经表明，在PM存在下，金黄色葡萄球菌的诱导变化加剧了感染。该项目将重点放在S。金黄色葡萄球菌与社区获得性感染有关。将研究细菌、宿主和空气污染之间的相互作用，以了解促进宿主上皮细胞粘附和侵袭增加的基因表达变化。

Air pollution is the world's largest single environmental health risk, being responsible for an eighth of all global deaths per year (World Health Organisation, 2017). Particulate matter (PM), a key component of air pollution, is strongly associated with exacerbation of chronic respiratory disease such as COPD and asthma, as well as community acquired pneumonia, infective endocarditis, infection of cystic fibrosis patients, otitis media and chronic rhinosinusitis. Previous work has shown induced changes in Staphylococcus aureus in the presence of PM that exacerbate infection. This project will focus on S. aureus associated with community acquired infection. The interplay between bacteria, host and air pollution will be investigated in order to understand gene expression changes that facilitate increased adhesion and invasion of host epithelial cells.