he impact of air pollution on host-pathogen interactions.

空气污染对宿主与病原体相互作用的影响。

• 批准号: 2737824
• 金额: --
• 依托单位: University of Leicester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2737824
• 关键词: he; impact; air; pollution; host

Air pollution is the world's largest single environmental health risk, being responsible for an eighth of all global deaths per year (World Health Organisation, 2017). Particulate matter (PM), a key component of air pollution, is strongly associated with exacerbation of chronic respiratory disease such as COPD and asthma, as well as community acquired pneumonia, infective endocarditis, infection of cystic fibrosis patients, otitis media and chronic rhinosinusitis. Previous work has shown induced changes in Staphylococcus aureus in the presence of PM that exacerbate infection. This project will focus on S. aureus associated with community acquired infection. The interplay between bacteria, host and air pollution will be investigated in order to understand gene expression changes that facilitate increased adhesion and invasion of host epithelial cells.

空气污染是世界上最大的单一环境健康风险，每年占全球死亡人数的八分之一(世界卫生组织，2017年)。颗粒物(PM)是空气污染的重要组成部分，与慢性阻塞性肺疾病、哮喘、社区获得性肺炎、感染性心内膜炎、囊性纤维化患者感染、中耳炎和慢性鼻窦炎等慢性呼吸道疾病的加重密切相关。以前的工作已经表明，在PM存在的情况下诱导金黄色葡萄球菌的变化，从而加剧感染。该项目将重点关注与社区获得性感染相关的金黄色葡萄球菌。将调查细菌、宿主和空气污染之间的相互作用，以了解促进宿主上皮细胞黏附和侵袭增加的基因表达变化。