Cellular and Molecular Microbiology Training Program

细胞和分子微生物学培训计划

• 批准号: 7123625
• 负责人: Jack J Hawiger
• 金额: $ 19.47万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7123625
• 关键词: Cellular; Molecular; Microbiology; Training; Program

DESCRIPTION (provided by applicant): This renewal application seeks support for continuation of a unique and timely research training program in Cellular and Molecular Microbiology conducted by an interdisciplinary group of faculty investigators at Vanderbilt University (VU) and Meharry Medical College (MMC). These investigators represent the coalescing disciplines of microbial pathogenesis and cell biology which evolve into the growing field of cellular microbiology. The Program offers trainees with research opportunities for new discoveries in the study of the pathogen-host interactions relevant to biodefense and other microbes that cause human diseases, including Severe Acute Respiratory Syndrome (SARS). The training faculty at VU and MMC has demonstrated a highly effective commitment to 13 predoctoral students supported by this Program. The innovative features of this program are vested in state-of-the-science cell biology approaches as applied to the study of organisms important for human pathogenesis in the following areas: (i) Host-Cell Interaction with Potential Bioweapon Agents and Development of Countermeasures; (ii) Virus-Cell Interactions; (iii) Microbial Adhesion to Cellular Receptors; (iv) Microbial Cues for Cytoskeleton, Cytokinesis and Cell Cycle; (v) Endosomal-Lysosomal Pathway of Microbial Internalization and Processing; (vi) Signal Transduction and Gene Transcription Evoked by Pathogens; (vii) Nuclear Import and Export; (viii) RNA and DNA Binding Proteins in Pathogen-Host Interaction; (ix) ER and Golgi Pathways for Microbial Peptides, Glycolipids, and Glycoproteins; and (x) Mitochondria and Microbial Strategy for Survival. This well-defined Program recruits predoctoral trainees with explicit interests in cellular microbiology of pathogen-host interactions from a pool of graduate and MD/PhD students who matriculated to VU and MMC and have indicated microbiology, virology, immunology, and/or molecular cell biology as their area(s) of interest. These students are offered the Program's flagship course, "Cellular Microbiology of the Pathogen-Host Interaction." The competing application also proposes inclusion of select summer undergraduate trainees, with special emphasis on underrepresented minorities, who seek a career in the biomedical sciences. The Program is based on a stringent selection and monitoring by the Steering Committee which promotes vigorous mentorship and scientific interactions between participating laboratories and early career counseling. The Program's overall mission is to interface trainees with a highly interactive group of VU/MMC faculty and to foster the career development of new pioneers in the field of cellular microbiology of the pathogen-host interactions.

描述(由申请人提供)：本次续签申请寻求支持范德比尔特大学(VU)和梅哈里医学院(MMC)一个由教研员组成的跨学科研究小组在细胞和分子微生物学方面继续开展独特和及时的研究培训计划。这些研究人员代表了微生物发病机制和细胞生物学的结合学科，它们演变为细胞微生物学日益增长的领域。该计划为学员提供了在与生物防御和其他导致人类疾病(包括严重急性呼吸综合征(SARS))的微生物相关的病原体-宿主相互作用研究方面的新发现的研究机会。威斯康星大学和密歇根州立大学的培训教师已经证明了对该项目支持的13名博士前学生的高度有效的承诺。这一计划的创新特点是应用最先进的细胞生物学方法研究对人类致病重要的生物体在以下领域：(I)宿主-细胞与潜在的生物武器制剂的相互作用和对策的开发；(Ii)病毒-细胞相互作用；(Iii)微生物 与细胞受体的黏附；(Iv)细胞骨架、胞质分裂和细胞周期的微生物信号；(V) 微生物内化和加工的内体-溶酶体途径；(Vi)病原体引起的信号转导和基因转录；(Vii)核进出口；(Viii)病原体-宿主相互作用中的RNA和DNA结合蛋白；(Ix)微生物多肽、糖脂和糖蛋白的内质网和高尔基体途径；以及(X)线粒体和微生物的生存策略。这一明确的课程从VU和MMC录取的研究生和医学博士/博士生中招募对病原体-宿主相互作用的细胞微生物学有明显兴趣的博士前实习生，并已将微生物学、病毒学、免疫学和/或分子细胞生物学作为他们的感兴趣领域(S)。这些学生被提供该项目的旗舰课程--“病原体-宿主相互作用的细胞微生物学”。这项竞争的申请还提议将精选的夏季本科实习生包括在内，特别强调未被充分代表的少数族裔，他们寻求生物医学科学的职业生涯。该方案基于指导委员会的严格挑选和监测，以促进积极的指导以及参与实验室和早期职业咨询之间的科学互动。该计划的总体使命是使受训者与VU/MMC教员组成的高度互动的小组进行接触，并促进病原体-宿主相互作用的细胞微生物学领域的新先驱的职业发展。