Institutional Research Cancer Epidemiology Fellowship

描述(由申请人提供)：本提案是对约翰霍普金斯大学彭博公共卫生学院癌症流行病学、预防和控制培训计划的NRSA机构研究资助的5年续期(24-28年)的申请的重新提交。该计划的使命是培养博士后学生和博士后研究员，使他们成为前沿的领导者，促进癌症原因的知识，包括遗传和可改变因素，以及如何通过更好地了解癌症相关行为，并在基于人群的研究中确定早期发现癌症的新标记物来预防癌症。该计划的目标是为学员创造一个丰富和互动的环境，并通过由公共卫生学院、基梅尔癌症中心和约翰·霍普金斯医疗机构的观察性、基础和临床科学家进行的高度创新、富有成效和协作性的癌症研究来加强。该方案的主题体现在3个互补的培训轨道中：1)癌症病因和预防；2)癌症遗传流行病学；以及3)癌症控制。7名博士后和4名博士后实习生追求一个由跨学科和跨学科的实质性和方法论问题以及研究伦理的共同要素组成的重点项目：关于学科内和跨学科的实质性和方法论问题的教学课程；互动信息交流，包括进展中的研究、研讨会和专题讨论会；教学、沟通、资助撰写经验；现有数据集的统计分析和通过流行病学和实验室癌症研究项目(博士后)进行短期轮换的实践经验；在在职导师的指导下进行博士后前或博士后研究；以及针对具体项目的教育、研究和职业指导。我们强调开发和测试基于生物学的新假说以及跨学科合作的重要性。通过共享元素，我们的学员接触到当前的问题，如转化研究、分子流行病学、癌症新出现的风险因素、癌症研究和筛查中的方法学问题、癌症差异、烟草控制、肥胖/能量平衡、炎症，以及在风险评估和公共政策中使用流行病学。修订后的计划建立在一个有着长期记录的计划的基础上，根据现任和前任受训人员、一名外部顾问和同行评审员的评估做出了重大改变。该计划的核心是19名导师，他们负责初级指导。另有39名附属教员以书面形式承诺提供特定癌症现场、生物统计学和基于实验室的暴露评估方面的专业知识；他们的聚集是为了给学员的经历带来广度和深度，并满足他们随着科学进步而不断变化的需求。指导委员会负责挑选和监督受训人员，并随着这些领域的进展完善培训计划。该提案记录了明确的培训和指导记录；在过去10年中任命的23名博士后和10名博士后实习生在癌症研究事业中取得了成功。从大量的申请者中，我们招募代表不同背景的最好的候选人。总而言之，该计划旨在为学员提供进行最高水平的最先进合作癌症研究所必需的多学科背景，培养创新思维以及教学和沟通能力，并为他们成为国家以人口为基础的癌症研究议程的领导者做好准备。

DESCRIPTION (provided by applicant): This proposal is a resubmission of an application for a 5-year renewal (Years 24-28) of an NRSA Institutional Research Grant for the training program in Cancer Epidemiology, Prevention, and Control at the Johns Hopkins Bloomberg School of Public Health. The program mission is to train pre-doctoral students and post-doctoral fellows to become leaders at the forefront of advancing the knowledge of the causes of cancer, including genetic and modifiable factors, and how to prevent cancer by providing a better understanding of cancer-related behaviors and identifying new markers for the early detection of cancer in population-based studies. The program goal is to create a rich and interactive environment for trainees augmented by the highly innovative, productive, and collaborative cancer research conducted by observational, basic, and clinical scientists at the School of Public Health, Kimmel Cancer Center, and Johns Hopkins Medical Institutions. The program themes are embodied in the 3 complementary training tracks: 1) Cancer Etiology and Prevention; 2) Genetic Epidemiology of Cancer; and 3) Cancer Control. The 7 pre- and 4 post-doctoral trainees pursue a focused program consisting of shared elements across the tracks: didactic courses in substantive and methodologic issues within and across disciplines and research ethics; interactive information exchange including research in progress, seminars, and symposium; teaching, communication, grant writing experiences; practical experiences of a statistical analysis of an existing dataset and short rotations through epidemiology and laboratory cancer research programs (pre-doc); pre- or post-doctoral research under an engaged preceptor; and program-specific education, research, and career mentoring. We stress the importance of developing and testing novel biologically based hypotheses and collaborating across disciplines. Via the shared elements, our trainees are exposed to current issues, such as translational research, molecular epidemiology, emerging risk factors for cancers, methodologic issues in cancer research and screening, cancer disparities, tobacco control, obesity/energy balance, inflammation, and use of epidemiology in risk assessment and public policy. The revised program builds on a program with a long track record, with major changes made in response to evaluations from current and former trainees, an external advisor, and peer reviewers. The program has a core of 19 preceptors who are responsible for primary mentoring. An additional 39 affiliated faculty have committed in writing to providing expertise in specific cancer sites, biostatistics, and laboratory based exposure assessment; they were assembled to bring breadth and depth to the trainees' experiences and to meet their changing needs as science advances. A Steering Committee is responsible for trainee selection and monitoring, and refinement of the training program as these fields progress. The proposal documents a clear record of training and mentorship; the 23 pre- and 10 post-doctoral trainees appointed in the past 10 years have cancer research career success. From a large pool of applicants, we recruit the best possible candidates who represent diverse backgrounds. In summary, the program is designed to provide trainees with the multidisciplinary background essential to conduct the highest caliber state-of-the-art collaborative cancer research, to nurture innovative thinking and the ability to teach and communicate, and to prepare them to be leaders in the Nation's population-based cancer research agenda.