Preventing Postpartum Depression in Adolescent Mothers

预防青春期母亲的产后抑郁症

• 批准号: 7128620
• 负责人: MAUREEN G PHIPPS
• 金额: $ 18.75万
• 依托单位: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7128620
• 关键词: adolescence (12-20); age at pregnancy; audiotape; behavioral /social science research tag; clinical research; clinical trials; female; focus groups; handbook; human subject; human therapy evaluation; interview; longitudinal human study; low socioeconomic status; medically underserved population; parents; patient oriented research; postpartum depression; prenatal care; psychological stressor; psychotherapy; questionnaires; racial /ethnic difference; role; social support network; therapy design /development; videotape /videodisc

DESCRIPTION (provided by applicant): The consequences of adolescent childbearing include significant social and health impacts on the parenting teens and their children. Each year, more than 400,000 births in the United States are to mothers less than 20 years old. Pregnant teenagers are at increased risk for adverse birth outcomes and parenting difficulties. Depression during the postpartum period transforms an already challenging process into a potentially overwhelming one. This hardship may be a major determinant of poor outcomes for these young mothers and their children. Clearly, the prevention of postpartum depression with this vulnerable population should be an integral part of prenatal care and of special interest to health care providers and policy makers. Unfortunately, virtually no research has examined the effects of a preventive intervention to reduce postpartum depression in pregnant teenagers. The objective of this treatment development grant is to develop a psychosocial intervention for financially disadvantaged, pregnant adolescents and to collect preliminary data on the efficacy of this intervention in reducing the degree of postpartum depression. The intervention is primarily an interpersonally-oriented intervention that targets those factors that may play a significant role in the development of postpartum depression in adolescent mothers (i.e., poor social support, role transitions, and life stressors). The specific aims of this project are to: (SA1) Develop the intervention program, including refining the intervention manual to reflect the needs of our target population, and developing adherence and competence scales, therapist training procedures, and research procedures for recruitment and retention of subjects; (SA2) Conduct a randomized controlled pilot study to evaluate the initial efficacy of the proposed intervention compared to a didactic control condition in a sample of 100 pregnant adolescents and to provide an estimate of effect size in comparison to the control condition; and, (SA3) Evaluate the pilot study results and procedures to inform the refinement of the intervention and procedures to prepare for a larger clinical trial evaluating the efficacy of this intervention. Findings from this study will have important implications for preventing significant morbidity in adolescent mothers and their children.

描述（由申请人提供）：青少年生育的后果包括对养育青少年及其子女的重大社会和健康影响。在美国，每年有超过40万的新生儿是由20岁以下的母亲所生。怀孕少女发生不良分娩结果和养育子女困难的风险增加。产后抑郁会把一个本来就充满挑战的过程变成一个潜在的压倒性的过程。这种困难可能是这些年轻母亲及其子女不良结局的主要决定因素。显然，预防这一弱势群体的产后抑郁症应该是产前护理的一个组成部分，也是卫生保健提供者和决策者特别关心的问题。不幸的是，几乎没有研究检验过预防性干预对减少怀孕少女产后抑郁的影响。这项治疗发展补助金的目的是为经济上处于不利地位的怀孕青少年开发一种社会心理干预措施，并收集有关这种干预措施在降低产后抑郁症程度方面的有效性的初步数据。干预主要是一种以人际关系为导向的干预，针对那些可能在青春期母亲产后抑郁症的发展中起重要作用的因素（即缺乏社会支持、角色转换和生活压力源）。该项目的具体目标是：（SA1）制定干预计划，包括完善干预手册以反映目标人群的需求，制定依从性和能力量表，治疗师培训程序，以及招募和保留受试者的研究程序；（SA2）开展一项随机对照先导研究，在100名怀孕青少年样本中评估拟议干预与教学对照条件相比的初步效果，并提供与对照条件相比的效应大小估计；（SA3）评估试点研究结果和程序，为干预措施的改进和程序提供信息，为评估该干预措施有效性的更大规模临床试验做准备。这项研究的结果将对预防青少年母亲及其子女的重大发病率具有重要意义。