Developmental Research Program

发展研究计划

• 批准号: 7198315
• 负责人: GEOFFREY L GREENE
• 金额: $ 5.81万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-11-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7198315
• 关键词: breast neoplasms; clinical research; spores; university

The objective of the University of Chicago Breast Cancer SPORE Developmental Research Program (DRP) is to create a streamlined and transparent mechanism for soliciting and selecting exciting and novel research projects that have significant potential for translational success. Such projects may be collaborative among scientists within our SPORE, or have collaborations outside the SPORE environment, but must be innovative, potentially high impact, and preferably multi-disciplinary. This program will be led by Dr. Geoffrey Greene, a leader in the estrogen receptor field with a strong interest in translating basic science to clinical breast cancer, and Dr. Suzanne Conzen, a physician-scientist and medical oncologist specializing in breast cancer whose laboratory uses large scale genomic approaches to identify novel anti-apoptotic signaling pathways contributing to the transformation of breast epithelial cells. Specifically, the SPORE DRP will 1) establish a mechanism for soliciting DRP applications that reaches beyond cancer center members and the local SPORE community to all biological, physical, computer and social science faculty members at the University of Chicago and Argonne National Laboratory, as well as to investigators at other SPOREs nationwide; 2) encourage, support, and nurture interdisciplinary collaboration using the expertise of our interdisciplinary Internal Scientific Advisory Committee; 3) select and assess projects that help generate new hypotheses for development as full-fledged SPORE projects.

芝加哥大学乳腺癌孢子发育研究项目的目标 (DRP)是建立一个精简和透明的机制，征求和选择令人兴奋的， 具有重大转化成功潜力的新研究项目。这些项目可能是 在我们的SPORE内的科学家之间进行合作，或者在SPORE外进行合作 环境，但必须是创新的，潜在的高影响力，最好是多学科。这 该项目将由杰弗里格林博士领导，他是雌激素受体领域的领导者，对雌激素受体有着浓厚的兴趣。 在将基础科学转化为临床乳腺癌方面，Suzanne Conzen博士是一位医生兼科学家， 专门从事乳腺癌的医学肿瘤学家，其实验室使用大规模基因组方法 鉴定有助于乳腺上皮细胞转化的新的抗凋亡信号通路， 细胞具体而言，SPORE DRP将1）建立一个征求DRP申请的机制， 超越癌症中心成员和当地的孢子社区， 芝加哥大学和阿贡国立大学的计算机和社会科学教员 实验室，以及全国其他SPORE的研究人员; 2）鼓励，支持和培养 利用我们的跨学科内部科学顾问的专业知识进行跨学科合作 委员会; 3）选择和评估有助于产生新的发展假设的项目， 孢子项目。