Mechanisms of Action

作用机制

• 批准号: 7299584
• 负责人: Derek C Angus
• 金额: $ 25.37万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-22 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7299584
• 关键词: biomarker; blood coagulation; human mortality; human subject; human therapy evaluation; hypoxia; inflammation; multiple organ failure; oxidative stress; patient care management; patient oriented research; resuscitation; septic shock; septicemia; thrombosis

The primary objectives of this subproject are to test the hypotheses: 1): Protocolized resuscitation reduces expression of circulating markers of: i.) inflammation, ii.) cellular hypoxia, iii.) oxidative stress, and iv.) coagulation/thrombosis. 2): The clinical efficacy of protocolized resuscitation is associated with reduced expression of circulating markers of: i.) inflammation, ii.) cellular hypoxia, iii.) oxidative stress, and iv.) coagulation/thrombosis.

这个子项目的主要目标是检验假设： 1）：方案化复苏减少以下循环标志物的表达：i.）炎症，ii.）细胞缺氧，iii.）氧化应激，和iv.）凝血/血栓形成。 2）：方案化复苏的临床功效与以下循环标志物的表达降低相关：i.）炎症，ii.）细胞缺氧，iii.）氧化应激，和iv.）凝血/血栓形成。