Center the Neurobiological Investigation of Drug Abuse

描述(由申请人提供)： 药物滥用神经生物学调查中心(CNIDA)是由NIDA提供的赠款于1991年成立的。该中心的具体目标是：提供一个环境，促进维克森林大学医学院科学家对药物滥用的神经生物学机制进行合作和多学科研究；重点培训学生和博士后，使用现代方法调查药物滥用的神经生物学基础；为非专业人员和科学界提供与药物滥用的神经生物学方面有关的问题的信息来源，并为社区的治疗和预防计划提供科学参考。中心将在下一个供资期间通过四个核心和七个项目的活动实现这些目标。这些核心(行政、动物、化学和PET成像)将为其专业知识从分子生物学到非人类灵长类自我管理的项目提供服务。这些项目多种多样，但他们的研究围绕着一个总的主题，即检查由于吸毒而在大脑中发生的神经元适应，以及调节从吸毒到吸毒成瘾的转变。这些项目利用了中心研究人员独特开发的几种动物模型和技术。来自维克森林大学医学院生理学-药理学和放射学系以及纽约州立大学布法罗分校化学系的大量教职员工和研究助理将直接参与中心的研究。该中心将继续为本科生、研究生和博士后研究员提供研究培训，并向科学界和非科学界提供药物滥用的神经生物学资源。

DESCRIPTION (provided by applicant): The Center for the Neurobiological Investigation of Drug Abuse (CNIDA) was established in 1991 by a grant from NIDA. The Specific Aims of the Center are: to provide an environment to promote collaborative and multidisciplinary research into the neurobiological mechanisms of drug abuse among scientists at Wake Forest University School of Medicine; to provide a focus for the training of students and postdoctoral fellows in contemporary methods for investigation of the neurobiological basis of drug abuse; and to serve as an information source to both the lay and scientific community on issues related to the neurobiological aspects of drug abuse and to serve as the scientific reference for treatment and prevention programs in the community. The Center will accomplish these goals through the activities of four cores and seven projects over this next funding period. The cores (Administration, Animal, Chemistry and PET Imaging) will provide services to the projects whose expertise spans from molecular biology to non-human primate self-administration. The projects are diverse, but their research encompasses a general theme to examine the neuronal adaptations occurring in brain as a result of drug use, and which mediate the transition from drug use to drug addiction. These projects utilize several animal models and technologies uniquely developed by the Center investigators. A large number (23) of faculty and research associates will directly participate in Center research, from the Departments of Physiology-Pharmacology and Radiology at Wake Forest University School of Medicine, as well as the Department of Chemistry at SUNY-Buffalo. The Center will continue to provide research training for undergraduates, graduate students and postdoctoral fellows and serve as a resource on the neurobiology of drug abuse to the scientific and lay communities.