Shellfish Kinetics

贝类动力学

• 批准号: 7186733
• 负责人: ALLAN DEVOL
• 金额: $ 4.6万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7186733
• 关键词: Bivalvia; Protista; affinity chromatography; algae; aquatic biology; aquatic organism; binding proteins; ecosystem; environmental health; environmental toxicology; field study; food chain contamination; gel filtration chromatography; ion exchange chromatography; marine toxins; neurotoxins; population genetics; public health; receptor binding; saltwater environment; seafood poisoning; toxin metabolism; two dimensional gel electrophoresis; water microbiology; water sampling /testing

Description (provided by applicant): The role of the Shellfish Kinetics Research Project component of this Center proposal is to: develop a predictive understanding of the physical, ecological and organismal processes that regulate the opportunity for benthic bivalves to accumulate and bind domoic acid as a result of filter feeding Pseudo-nitzschia spp. and other microscopic algae bearing marine toxins. The overall objective is to integrate the oceanography and domoic acid on the Pacific Coast and oceanography and domoic acid in Puget Sound investigations with the human health and risk assessment components of the Center (see Human Exposure Research Project and the Informatics Facility Core). The investigators will directly interface with the oceanography and domoic acid in Puget Sound component through the comparison of acute domoic acid toxicity along the coast (where domoic acid is an acute problem) to the Puget Sound (where there are only chronic low-level exposures, with essentially no acute domoic acid toxicity). To achieve these goals the investigators have separated the Shellfish Kinetics Research Project into two projects. Project 1 will focus on comparisons between offshore/neritic and nearshore regions, with the specific goal of understanding the mechanisms underlying the flux of toxic algae from the water column into near shore benthic bivalves. The second project seeks to follow the consequence of bivalve assimilation of domoic acid.

描述（由申请人提供）：该中心提案的贝类动力学研究项目组成部分的作用是：对物理、生态和生物过程形成预测性理解，这些过程调节底栖双壳类因滤食拟菱形藻而积累和结合软骨藻酸的机会。以及其他携带海洋毒素的微小藻类。总体目标是将太平洋沿岸的海洋学和软骨藻酸以及普吉特湾调查中的海洋学和软骨藻酸与该中心的人类健康和风险评估部分相结合（参见人类暴露研究项目和信息学设施核心）。研究人员将通过比较沿海地区（软骨藻酸是一个严重问题）和普吉特海湾（那里只有慢性低水平暴露， 基本上没有软骨藻酸急性毒性）。为了实现这些目标，研究人员将贝类动力学研究项目分为两个项目。 项目 1 将侧重于近海/浅海和近岸区域之间的比较，具体目标是了解有毒藻类从水柱流入近岸底栖双壳类的潜在机制。第二个项目旨在追踪双壳类动物同化软骨藻酸的后果。