Novel utilisation of trigeminal stimulants as bioactive ingredients to design innovative and improved oral-care formulations in scientific and sustain

世界卫生组织（2020年）报告称，超过35亿人患有口腔疾病1，科学证明牙齿健康状况不佳与心脏病、糖尿病、肥胖和口腔癌有关2。口腔护理产品用于清洁口腔，保持良好的口腔卫生，在口腔疾病的日常预防中起着至关重要的作用。与传统的口腔护理产品主要使用薄荷化合物来刺激凉爽的感觉不同，该提案的独特目的是i）产生关于不同三叉神经兴奋剂在口腔中的功能的基础知识，ii）探索它们的潜在用途，以帮助设计更有效和新颖的配方。

Background& Aims The World Health Organization (2020) reported thatmore than 3.5 billion people suffer from oral disease1, and poor dental health has been scientifically proven for itslink withheartdisease, diabetes, obesity,andmouth cancer2. Oral-care products, which areused to cleanse the oral cavityand maintain good oral hygiene, play a vital rolein the dailypreventionof oral disease. Unlike the traditional oral-care productsmainlyusingminty compoundsto stimulate a cooling sensation, this proposal uniquely aims toi)generate fundamental knowledgeon the functionality of differenttrigeminal stimulantsin the oral cavity andii)explore their potential use tohelpdesignmore efficacious and novelformulations.