ACT 7: AIDS & EMERGING INFECTIOUS DISEASES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项提案的主要目标是建立一个方案，以加强艾滋病和新发传染病的研究能力。之所以选择这两个重点项目，是因为岛上的艾滋病毒发病率很高，而且新出现或再出现的疾病对波多黎各这个热带加勒比岛屿构成了真正的威胁。多学科项目允许我们的基础和临床科学家完成他们的目标所需的资源和专业知识的整合。该项目由两个部分组成：一个核心设施，提供在医学院不易获得的最先进设备；并为新教师、博士后研究员和学生提供培训。此外，该项目还整合了我们的临床和基础研究人员，以便能够更快地应对当地社区面临的新传染病威胁。本提案中包含的四个原始正在进行的项目是：项目1“普遍定期审议成人艾滋病临床试验单元-幼稚患者HIV基因分型”项目2“趋化因子受体在跨胎盘HIV感染中的作用”项目3“登革热-2包膜dna疫苗的评价研究”项目4“啮齿动物疟疾多药耐药基因鉴定”。这些项目处理与波多黎各和加勒比人口有关的保健差距问题。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main objective of this proposal was to create a program to enhance research capabilities in AIDS and Emerging Infectious Diseases. These two foci of the program were chosen because of the high incidence of HIV on the island, as well as the real threat which emerging or re-emerging diseases pose to Puerto Rico, a tropical Caribbean island. the multidisciplinary program allowed the integration of the resources and expertise needed by our basic and clinical scientists to accomplish their goals. The project consisted of two components: a core facility providing state-of-the-art equipment not easily available at the Medical Sciences Campus; and a training component for new faculty, post-doctoral fellows and students. In addition, this program served to integrate our clinical and basic research faculty in order to be equipped to respond more rapidly to new infectious disease threats to the local community. The four original ongoing projects included in this proposal were: Project No. 1 "UPR Adult AIDS Clinical Trials Unit - HIV genotyping in naive patients" Project No. 2 "Role of Chemokine Receptors in HIV Infection Across the Placenta" Project No. 3 "Evaluation Studies of Dengue-2 Envelope DNA-Based Vaccine" Project No. 4 "Identification of Multidrug Resistant Genes in Rodent Malaria". These projects address health disparities issues relevant to the Puerto Rican and Caribbean populations.