Topological design of anti-fouling surfaces for biomedical devices

生物医学设备防污表面的拓扑设计

• 批准号: 2746263
• 金额: --
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2746263
• 关键词: Topological; design; anti; fouling; surfaces

Significant incidence of hospital-acquired infections due to fouling of biomedical devices is a major threat contributing to prolonged hospital stay and death. Specifically, invasion of bacteria to human bodies via surgical instruments and catheters is made utterly easy by the presence of liquids such as urine, blood and even water/moisture. In this project, robust liquid-repellent surfaces with biofouling-resistant properties will be topologically designed to prevent contamination on biomedical devices. State-of-the-art fabrication techniques (3D printing and laser-based machining) will be used to create distinct surface topologies. This will lead to inherent anti-fouling properties by preventing wetting andadhesion of contaminating liquids.

由于生物医学设备的污染，医院获得性感染的发生率很高，这是导致住院时间延长和死亡的主要威胁。具体来说，细菌通过手术器械和导管侵入人体是非常容易的，因为存在液体，如尿液、血液甚至水/湿气。在这个项目中，具有抗生物污垢特性的坚固的液体排斥表面将被拓扑设计，以防止生物医学设备上的污染。最先进的制造技术（3D打印和激光加工）将用于创建不同的表面拓扑结构。这将导致固有的防污性能，通过防止润湿和粘附的污染液体。