Doctoral Research Project Title

博士研究项目名称

• 批准号: 2746406
• 金额: --
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2746406
• 关键词: Doctoral; Research; Project; Title

Despite rapid expansion and being one of the most promising methods for key synthetic transformations in chemistry, photocatalysis is hindered by the reliance on expensive precious metal-based catalysts, poor catalytic lifetimes and high catalyst loadings. A significant dependence on Ru(II) and Ir(III) catalysts, causes economic and environmental challenges, as both are expensive, precious metals. (1) A limited understanding of, and inability to prevent, catalyst decomposition means poor catalytic lifetimes leading to high catalyst loadings. (1) To overcome these challenges the initial approach will investigate economically more sustainable Cu based photocatalytic systems with the potential integration of ligands such as novel N-heterocyclic carbene (NHC). Cu(NHC) complexes are easily synthesised implementing simple, cheap and flexible processes such as electrochemical techniques, allowing for ready optimisation of their stability and performance. (2) These will be fully characterised and deployed in test photochemical reactions of pharmaceutical relevance (e.g. Minisci reactions, heteroatom arylation). Developing a scalable process is an important consideration for photochemical transformations, so running the reactions in a continuous flow process will be vital for successful transfer to an industry setting. Once synthetic methodology is established the project will investigate deployment in lab-based flow systems.

尽管光催化发展迅速，并且是化学中关键合成转化最有前途的方法之一，但由于对昂贵的贵金属催化剂的依赖、催化寿命差和催化剂负载量高，光催化受到阻碍。对 Ru(II) 和 Ir(III) 催化剂的严重依赖会带来经济和环境挑战，因为两者都是昂贵的贵金属。 (1) 对催化剂分解的了解有限且无法预防，这意味着催化寿命较差，导致催化剂负载量较高。 (1) 为了克服这些挑战，最初的方法将研究经济上更可持续的铜基光催化系统，并可能集成新型 N-杂环卡宾 (NHC) 等配体。 Cu(NHC) 配合物很容易合成，采用简单、廉价和灵活的工艺（例如电化学技术），可以随时优化其稳定性和性能。 (2) 这些将被充分表征并部署在与药物相关的测试光化学反应中（例如 Minisci 反应、杂原子芳基化）。开发可扩展的工艺是光化学转化的一个重要考虑因素，因此在连续流程中运行反应对于成功转移到工业环境至关重要。一旦建立了合成方法，该项目将研究在基于实验室的流动系统中的部署。