Genomic epidemiology of SARS-CoV-2 in EastAnglia

EastAnglia SARS-CoV-2 的基因组流行病学

• 批准号: 2746477
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2746477
• 关键词: Genomic; epidemiology; SARS; CoV; EastAnglia

The UK is a world leader in SARS-CoV-2 genome sequencing thanks to the COVID-19 Genomics UK Consortium (COG-UK). The Quadram Institute, in particular the Page group, have been at the forefront of sequencing SARS-CoV-2 genomes with over 60,000 sequenced in 18 months making Norfolk the most densely sequenced region of England. This project focuses on looking more deeply at how the pandemic unfolded within this region to gain a deep understanding of the genomic epidemiology which will help to inform future management of infectious diseases. Using genomics, the aim is to seek answers to questions like: how did the Alpha variant spread within the region, what happened during hospital outbreaks, did different aged people spread the virus in different ways, were samples from closed environments like prisons linked to the local community, did trends from random community surveillance match up with trends seen in hospitals? This builds upon existing research which looked at the early days of the pandemic (https://dx.doi.org/10.1099%2Fmgen.0.000589).

由于COVID-19基因组学英国联盟（COG-UK），英国在SARS-CoV-2基因组测序方面处于世界领先地位。Quadram研究所，特别是Page小组，一直处于SARS-CoV-2基因组测序的最前沿，在18个月内测序了6万多个基因组，使诺福克成为英格兰测序最密集的地区。该项目的重点是更深入地研究该流行病如何在该地区展开，以深入了解基因组流行病学，这将有助于为未来的传染病管理提供信息。使用基因组学，目的是寻求诸如以下问题的答案：阿尔法变异如何在该地区传播，在医院爆发期间发生了什么，不同年龄的人是否以不同的方式传播病毒，来自监狱等封闭环境的样本是否与当地社区有关，随机社区监测的趋势是否与医院中观察到的趋势相匹配？这是建立在现有研究的基础上的，这些研究着眼于大流行的早期（https：//dx.doi.org/10.1099%2Fmgen.0.000589）。