Exploring the function of exosomes in Mycobacterium tuberculosis host-pathogen interaction, and their effect on infection outcome

探索外泌体在结核分枝杆菌宿主-病原体相互作用中的功能及其对感染结果的影响

• 批准号: 2747577
• 金额: --
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2747577
• 关键词: Exploring; function; exosomes; Mycobacterium; tuberculosis

In summary, we aim to dissect the role that exosomes released by Mtb-infected cells have in contributing to the aberrant immune response seen in granuloma formation and the dissemination of tuberculosis as a disease. We further want to characterise the effect of these exosomes on infection outcome, by highlighting cargo molecules, such as proteins and miRNAs, that may be key to the expansive inflammation seen in tuberculosis despite few infected cells being present. We believe these exosomes, released by infected cells, are eliciting a phenotypic switch in bystander cells similar to that of direct Mtb interaction, encouraging dysregulation of inflammation.

总之，我们的目的是剖析mtb感染细胞释放的外泌体在肉芽肿形成和结核病传播中所见的异常免疫反应中的作用。我们进一步想通过强调货物分子（如蛋白质和mirna）来表征这些外泌体对感染结果的影响，尽管很少有感染细胞存在，但这些货物分子可能是结核病中观察到的扩散性炎症的关键。我们相信这些被感染细胞释放的外泌体在旁观者细胞中引发了一种类似于结核分枝杆菌直接相互作用的表型转换，从而促进了炎症的失调。