Clinical Trial Development in Chronic Pelvic Pain Syndr*

慢性盆腔疼痛综合征的临床试验进展*

• 批准号: 7046060
• 负责人: Daniel Shoskes
• 金额: $ 25.91万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-07 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7046060
• 关键词: Hispanic Americans; chronic pain; clinical research; clinical trials; cystoscopy; experimental designs; human subject; human therapy evaluation; hyperthermia therapy; hypertrophy; interdisciplinary collaboration; male; patient oriented research; prostatitis; quality of life; urinalysis; urinary catheterization

DESCRIPTION (provided by applicant): Chronic Pelvic Pain Syndrome (CPPS) is a prevalent multifactorial disorder with variable and often disappointing response to therapy. There is evidence for infection, inflammation and neuromuscular spasm as the underlying cause in different patients despite identical clinical presentation. Large multicenter clinical trials are required to help delineate effective therapies and to identify which patients have the highest chance of success for a particular intervention. The Chronic Prostatitis Clinic at the Cleveland Clinic Florida has a high volume of patients, both newly diagnosed and longstanding. We have done numerous clinical trials in chronic prostatitis with rapid enrolment, 100% accrual of set targets and high rates of retention. We have a team of clinical specialists in allied fields important to the understanding of this condition, including experts in erectile dysfunction, rectal dysfunction, chronic pain management, complementary therapies (acupuncture, phytotherapy) and neuropsychology. We also maintain a basic science laboratory which would be equipped to perform any necessary molecular or biochemical ancillary studies such as real time PCR, oxidative stress markers, cytokines and genetic polymorphisms. Through our participation in the CPCRN and first NIH chronic prostatitis randomized clinical trial, we have demonstrated the ability to work collaboratively and to participate in study design and execution. As an example of a potential clinical trial, a study of water induced thermotherapy is outlined.

描述（由申请人提供）：